Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Jonasson, J G
Agnarsson, B A
Bergthorsson, J T
Barkardottir, R B
MetadataShow full item record
CitationInt. J. Cancer 1995, 64(6):378-82
AbstractPrimary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with microsatellite markers restricted to a 28 cM region including the MTS1 gene. LOH was found with at least 1 marker in 38% of the 201 cases analyzed. A high frequency of deletions was detected at the 9p23-p21 region, indicating a tumor suppressor gene(s) important for breast cancer tumorigenesis. Tumors with and without LOH on 9p were compared with respect to clinico-pathological factors using chi 2 analysis. Tumors with 9p LOH were significantly associated with high S-phase status and aneuploidy, but not with type, node status, estrogen and progesterone receptor content or age of the patients at diagnosis. Survival analysis showed that LOH at 9p did not significantly affect the survival rate of breast cancer patients. Our results indicate that the aberrations on 9p detected in this study are not of independent prognostic value. A significant association was found between LOH at 9p and LOH at chromosomal arms 3p and 6q, which is an additional contribution toward understanding the genetic events in breast tumor pathogenesis.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Loss of heterozygosity at chromosome 1p in human breast cancer.
- Authors: Ragnarsson G, Sigurdsson A, Eiriksdottir G, Barkardottir R, Jonasson J, Ingvarsson S
- Issue date: 1996 Oct
- Tumour suppressor gene (CDKNA2) status on chromosome 9p in resected renal tissue improves prognosis of localised kidney cancer.
- Authors: El-Mokadem I, Kidd T, Pratt N, Fleming S, Nabi G
- Issue date: 2016 Nov 8
- High frequency of LOH at chromosome 18q in human breast cancer: association with high S-phase fraction and low progesterone receptor content.
- Authors: Huiping C, Eiriksdottir G, Sigurdsson A, Sigurgeirsdottir JR, Barkardottir RB, Egilsson V, Ingvarsson S
- Issue date: 1998 Mar-Apr
- Fractional allele loss data indicate distinct genetic populations in the development of non-small-cell lung cancer.
- Authors: Field JK, Neville EM, Stewart MP, Swift A, Liloglou T, Risk JM, Ross H, Gosney JR, Donnelly RJ
- Issue date: 1996 Dec
- Chromosome 8p alterations in sporadic and BRCA2 999del5 linked breast cancer.
- Authors: Sigbjörnsdottir BI, Ragnarsson G, Agnarsson BA, Huiping C, Barkardottir RB, Egilsson V, Ingvarsson S
- Issue date: 2000 May