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Surgical treatment of patients with low-grade astrocytomas and medically intractable seizures

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Authors
Gunnarsson, T
Olafsson, E
Sighvatsson, V
Hannesson, B
Issue Date
2002-04-01

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Citation
Acta Neurol. Scand. 2002, 105(4):289-92
Abstract
OBJECTIVE: Low-grade astrocytomas can present with seizures that respond poorly to antiseizure medications, with a consequent reduction in the quality of life, because of both seizures and the medication's side-effects. We report our experience with operative treatment of such patients. SUBJECTS AND METHODS: Five patients (two children and three adults) with supratentorial low-grade astrocytomas associated with severe seizures were operated on. We followed the effects of the operation on post-operative neurological deficit, seizure frequency and the quality of life. RESULTS: No serious neurological complications followed the operations. The patients were followed for a median period of 12 months (6-46). Post-operatively, three of the patients became seizure-free, one experiences only auras, and one had a great reduction in seizure frequency and severity. All patients reported great improvement in their quality of life. CONCLUSION: Resections of low-grade astrocytomas in patients with medically intractable seizures are safe procedures that effectively control seizures in the majority of patients, resulting in significant improvement in the patients' quality of life.
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http://dx.doi.org/10.1034/j.1600-0404.2002.0o138.x
ae974a485f413a2113503eed53cd6c53
10.1034/j.1600-0404.2002.0o138.x
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