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dc.contributor.authorStyrkarsdottir, Unnur
dc.contributor.authorHalldorsson, Bjarni V
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorTang, Nelson L S
dc.contributor.authorKoh, Jung-Min
dc.contributor.authorXiao, Su-mei
dc.contributor.authorKwok, Timothy C Y
dc.contributor.authorKim, Ghi Su
dc.contributor.authorChan, Juliana C N
dc.contributor.authorCherny, Stacey
dc.contributor.authorLee, Seung Hun
dc.contributor.authorKwok, Anthony
dc.contributor.authorHo, Suzanne
dc.contributor.authorGretarsdottir, Solveig
dc.contributor.authorKostic, Jelena Pop
dc.contributor.authorPalsson, Stefan T
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorSham, Pak C
dc.contributor.authorKim, Beom-Jun
dc.contributor.authorKung, Annie W C
dc.contributor.authorKim, Shin-Yoon
dc.contributor.authorWoo, Jean
dc.contributor.authorLeung, Ping-C
dc.contributor.authorKong, Augustine
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorStefansson, Kari
dc.date.accessioned2010-11-01T09:47:23Z
dc.date.available2010-11-01T09:47:23Z
dc.date.issued2010-10
dc.date.submitted2010-11-01
dc.identifier.citationPLoS ONE. 2010, 5(10):e13217en
dc.identifier.issn1932-6203
dc.identifier.pmid20949110
dc.identifier.doi10.1371/journal.pone.0013217
dc.identifier.urihttp://hdl.handle.net/2336/114275
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urlhttp://dx.doi.org/10.1371/journal.pone.0013217en
dc.subject.meshBone Densityen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshQuantitative Trait Locien
dc.subject.meshFractures, Boneen
dc.titleEuropean bone mineral density loci are also associated with BMD in East-Asian populationsen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland. unnur.styrkarsdottir@decode.isen
dc.identifier.journalPloS oneen
html.description.abstractMost genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment of the influence of the sequence variants on populations of other ethnicities. To determine whether markers that we have recently shown to associate with Bone Mineral Density (BMD) in Europeans also associate with BMD in East-Asians we analysed 50 markers from 23 genomic loci in samples from Korea (n = 1,397) and two Chinese Hong Kong sample sets (n = 3,869 and n = 785). Through this effort we identified fourteen loci that associated with BMD in East-Asian samples using a false discovery rate (FDR) of 0.05; 1p36 (ZBTB40, P = 4.3×10(-9)), 1p31 (GPR177, P = 0.00012), 3p22 (CTNNB1, P = 0.00013), 4q22 (MEPE, P = 0.0026), 5q14 (MEF2C, P = 1.3×10(-5)), 6q25 (ESR1, P = 0.0011), 7p14 (STARD3NL, P = 0.00025), 7q21 (FLJ42280, P = 0.00017), 8q24 (TNFRSF11B, P = 3.4×10(-5)), 11p15 (SOX6, P = 0.00033), 11q13 (LRP5, P = 0.0033), 13q14 (TNFSF11, P = 7.5×10(-5)), 16q24 (FOXL1, P = 0.0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians.


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