New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationAnn. Hum. Genet. 1999, 63(Pt 3):235-47
AbstractGenetic linkage of schizophrenia to markers at 5q11.2-13.3 had been reported previously in five Icelandic and two British families, but attempts at replication in independent samples have been unsuccessful. We report here an update on the diagnoses and results of linkage analyses using newer highly polymorphic microsatellite markers at or near the loci D5S76 and D5S39 in the original sample of pedigrees and in two new family samples from Iceland and from Britain. The new results show a reduction in evidence for linkage in the original sample and evidence against linkage in the two new family samples. Although it is possible that a rare locus is present, perhaps in the region 5p14.1-13.1 rather than 5q11.2-13.3, it appears most likely that the original positive lod scores represent an exaggeration of the 'true' lod scores due to random effects and that the small lod scores we now obtain could have arisen by chance.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.
- Authors: Campion D, d'Amato T, Laklou H, Sabate O, Jay M, Leboyer M, Malafosse A, Gorwood P, Babron MC, Hillaire D
- Issue date: 1992 Dec
- Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q.
- Authors: Kaufmann CA, DeLisi LE, Lehner T, Gilliam TC
- Issue date: 1989
- Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.
- Authors: Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D
- Issue date: 2001 Mar
- Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders.
- Authors: Detera-Wadleigh SD, Goldin LR, Sherrington R, Encio I, de Miguel C, Berrettini W, Gurling H, Gershon ES
- Issue date: 1989 Aug 3
- A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76.
- Authors: Melmer G, Sherrington R, Mankoo B, Kalsi G, Curtis D, Gurling HM
- Issue date: 1991 Nov