Show simple item record

dc.contributor.authorIngvarsson, S
dc.date.accessioned2010-11-02T11:30:28Z
dc.date.available2010-11-02T11:30:28Z
dc.date.issued1999
dc.date.submitted2010-11-02
dc.identifier.citationAnticancer Res. 1999, 19(4B):2853-61en
dc.identifier.issn0250-7005
dc.identifier.pmid10652564
dc.identifier.urihttp://hdl.handle.net/2336/114366
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractGermline alterations of the BRCA1 or BRCA2 genes result in susceptibility to breast and ovarian cancer. Protein-protein interaction studies, transcription activity and mouse knockout experiments have suggested that the Brca1 and Brca2 proteins are of importance in DNA repair and maintenance of genome integrity, possibly due to the transactivation function of Brca1 or Brca2. Subsequently, tumors in individuals carrying germline mutation in either BRCA1 or BRCA2 gene show instability at chromosomal and gene level. Chromosomal and gene alterations are more pronounced in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic tumors. Furthermore, BRCA1 and BRCA2 mutated breast tumors differ from sporadic tumors in respect to histological phenotype. Typically, a higher grade of malignancy is observed in familial tumors. This review summarizes the putative functions of the Brca1 and Brca2 proteins and pathogenesis in tumors of BRCA1 and BRCA2 mutation carriers.
dc.language.isoenen
dc.publisherJ.G. Delinassios, Anticancer Researchen
dc.subject.meshAnimalsen
dc.subject.meshBRCA1 Proteinen
dc.subject.meshBRCA2 Proteinen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshLoss of Heterozygosityen
dc.subject.meshMiceen
dc.subject.meshMice, Knockouten
dc.subject.meshMutationen
dc.subject.meshNeoplasm Proteinsen
dc.subject.meshOvarian Neoplasmsen
dc.subject.meshPhenotypeen
dc.subject.meshTranscription Factorsen
dc.titleThe Brca1 and Brca2 proteins and tumor pathogenesisen
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University Hospital of Iceland, Reykjavik, Iceland. siguring@rsp.isen
dc.identifier.journalAnticancer researchen
html.description.abstractGermline alterations of the BRCA1 or BRCA2 genes result in susceptibility to breast and ovarian cancer. Protein-protein interaction studies, transcription activity and mouse knockout experiments have suggested that the Brca1 and Brca2 proteins are of importance in DNA repair and maintenance of genome integrity, possibly due to the transactivation function of Brca1 or Brca2. Subsequently, tumors in individuals carrying germline mutation in either BRCA1 or BRCA2 gene show instability at chromosomal and gene level. Chromosomal and gene alterations are more pronounced in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic tumors. Furthermore, BRCA1 and BRCA2 mutated breast tumors differ from sporadic tumors in respect to histological phenotype. Typically, a higher grade of malignancy is observed in familial tumors. This review summarizes the putative functions of the Brca1 and Brca2 proteins and pathogenesis in tumors of BRCA1 and BRCA2 mutation carriers.


This item appears in the following Collection(s)

Show simple item record