A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsLindqvist, A K
Terwilliger, J D
Gyllensten, U B
Alarcón-Riquelme, M E
MetadataShow full item record
CitationJ. Autoimmun. 2000, 14(2):169-78
AbstractTo identify chromosomal regions containing susceptibility loci for systemic lupus erythematosus (SLE), we performed genome scans in families with multiple SLE patients from Iceland, a geographical and genetic isolate, and from Sweden. A number of chromosomal regions showed maximum lod scores (Z) indicating possible linkage to SLE in both the Icelandic and Swedish families. In the Icelandic families, five regions showed lod scores greater than 2.0, three of which (4p15-13, Z=3.20; 9p22, Z=2.27; 19q13, Z=2.06) are homologous to the murine regions containing the lmb2, sle2 and sle3 loci, respectively. The fourth region is located on 19p13 (D19S247, Z=2.58) and the fifth on 2q37 (D2S125, Z=2.06). Only two regions showed lod scores above 2.0 in the Swedish families: on chromosome 2q11 (D2S436, Z=2. 13) and 2q37 (D2S125, Z=2.18). The combination of both family sets gave a highly significant lod score at D2S125 of Z=4.24 in favor of linkage for 2q37. This region represents a new locus for SLE. Our results underscore the importance of studying well-defined populations for genetic analysis of complex diseases such as SLE.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus.
- Authors: Magnusson V, Lindqvist AK, Castillejo-López C, Kristjánsdottir H, Steinsson K, Gröndal G, Sturfelt G, Truedsson L, Svenungsson E, Lundberg I, Gunnarsson I, Bolstad AI, Haga HJ, Jonsson R, Klareskog L, Alcocer-Varela J, Alarcón-Segovia D, Terwilliger JD, Gyllensten UB, Alarcón-Riquelme ME
- Issue date: 2000 Dec 15
- Characterization of a susceptibility locus for SLE, SLEB5, on chromosome 4p14-13.
- Authors: Johansson CM, Kristjánsdottir H, Gröndal G, Steinsson K, Alarcón-Riquelme ME
- Issue date: 2006 Sep
- A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups.
- Authors: Johanneson B, Steinsson K, Lindqvist AK, Kristjánsdóttir H, Gröndal G, Sandino S, Tjernström F, Sturfelt G, Granados-Arriola J, Alcocer-Varela J, Lundberg I, Jonasson I, Truedsson L, Svenungsson E, Klareskog L, Alarcón-Segovia D, Gyllensten UB, Alarcón-Riquelme ME
- Issue date: 1999 Aug
- Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3.
- Authors: Nath SK, Namjou B, Garriott CP, Frank S, Joslin PA, Kilpatrick J, Kelly JA, Harley JB
- Issue date: 2004 May
- SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations.
- Authors: Nath SK, Kelly JA, Reid J, Lam T, Gray-McGuire C, Namjou B, Aston CE, Harley JB
- Issue date: 2002 Jul