Cause-specific mortality in adults with unprovoked seizures. A population-based incidence cohort study
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationNeuroepidemiology. 2001, 20(4):232-6
AbstractPURPOSE: To determine the cause-specific mortality relative to that expected in a population-based incidence cohort of people with unprovoked seizures. METHODS: The cohort comprises 224 inhabitants of Iceland first diagnosed as suffering from unprovoked seizures during a 5-year period from 1960 to 1964. The expected number of deaths was calculated by multiplying person-years of observation within 5-year age categories for each year from diagnosis through 1995 by cause-specific and sex-specific national death rates for those aged 20 years and above. The standardized mortality ratio (SMR) and 95% confidence intervals (95% CI) were calculated. RESULTS: All-cause mortality was increased among men (SMR 2.25, 95% CI 1.56-3.14) but not women (SMR 0.79, 95% CI 0.38-1.46). Among men, there were 8 deaths from accidents, poisoning and violence observed versus 2.82 expected (SMR 2.84, 95% CI 1.22-5.59) and 4 deaths from suicide versus 0.69 expected (SMR 5.80, 95% CI 1.56-14.84). All-cause mortality for men was still elevated after restriction of analysis to those with seizures of unknown etiology (SMR 1.73, 95% CI 1.05-2.67) with the excess deaths attributable to suicide (SMR 5.26, 95% CI 1.06-15.38). Both males and females with remote symptomatic unprovoked seizures had an increase in all-cause mortality due to excess mortality from all cancers, cerebrovascular disease and accidents. CONCLUSION: When compared with the age-, time-period- and gender-specific mortality in the general population, there is excess mortality in men but not women. The increased mortality for men is partly attributable to excess mortality from accidents and suicides.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Long-term survival of people with unprovoked seizures: a population-based study.
- Authors: Olafsson E, Hauser WA, Gudmundsson G
- Issue date: 1998 Jan
- Causes that Contribute to the Excess Mortality Risk in Multiple Sclerosis: A Population-Based Study.
- Authors: Kingwell E, Zhu F, Evans C, Duggan T, Oger J, Tremlett H
- Issue date: 2020
- Mortality risk in an adult cohort with a newly diagnosed unprovoked epileptic seizure: a population-based study.
- Authors: Lindsten H, Nyström L, Forsgren L
- Issue date: 2000 Nov
- Causes of death in remote symptomatic epilepsy.
- Authors: Day SM, Wu YW, Strauss DJ, Shavelle RM, Reynolds RJ
- Issue date: 2005 Jul 26
- Mortality in patients with a first unprovoked seizure.
- Authors: Beghi E, Leone M, Solari A
- Issue date: 2005