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Authors
Fridriksson, JuliusKjartansson, Olafur
Morgan, Paul S
Hjaltason, Haukur
Magnusdottir, Sigridur
Bonilha, Leonardo
Rorden, Christopher
Issue Date
2010-08-18
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J. Neurosci. 2010, 30(33):11057-61Abstract
Patients with left hemisphere damage and concomitant aphasia usually have difficulty repeating others' speech. Although impaired speech repetition, the primary symptom of conduction aphasia, has been associated with involvement of the left arcuate fasciculus, its specific lesion correlate remains elusive. This research examined speech repetition among 45 stroke patients who underwent aphasia testing and MRI examination. Based on lesion-behavior mapping, the primary structural damage most closely associated with impaired speech repetition was found in the posterior portion of the left arcuate fasciculus. However, perfusion-weighted MRI revealed that tissue dysfunction, in the form of either frank damage or hypoperfusion, to the left inferior parietal lobe, rather than the underlying white matter, was associated with impaired speech repetition. This latter result suggests that integrity of the left inferior parietal lobe is important for speech repetition and, as importantly, highlights the importance of examining cerebral perfusion for the purpose of lesion-behavior mapping in acute stroke.Description
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http://dx.doi.org/10.1523/JNEUROSCI.1120-10.2010ae974a485f413a2113503eed53cd6c53
10.1523/JNEUROSCI.1120-10.2010
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