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dc.contributor.authorRosano, Caterina
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorSiggeirsdottir, Kristin
dc.contributor.authorPhillips, Caroline L
dc.contributor.authorGarcia, Melissa
dc.contributor.authorJonsson, Palmi V
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorNewman, Anne B
dc.contributor.authorHarris, Tamara B
dc.contributor.authorvan Buchem, Mark A
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorLauner, Lenore J
dc.date.accessioned2010-12-20T13:34:02Z
dc.date.available2010-12-20T13:34:02Z
dc.date.issued2010-07-01
dc.date.submitted2010-12-20
dc.identifier.citationNeurobiol. Aging. 2010, 31(7):1197-204en
dc.identifier.issn1558-1497
dc.identifier.pmid18774624
dc.identifier.doi10.1016/j.neurobiolaging.2008.08.004
dc.identifier.urihttp://hdl.handle.net/2336/118171
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To assess whether markers of micro- and macrostructural brain abnormalities are associated with slower gait in older men and women independent of each other, and also independent of health-related conditions and of behavioral, cognitive and peripheral function. METHODS: Magnetization transfer ratio [MTR], white matter hyperintensities [WMH], brain atrophy [BA] and brain infarcts [BI] were measured in 795 participants of the AGES-Reykjavik Study cohort (mean 75.6 years, 58.9% women). RESULTS: In women, lower MTR, higher WMH and BA, but not BI, remained associated with slower gait independent of each other and of other covariates. In men, WMH and BA, but not MTR or BI, remained associated with slower gait independently of each other. Only muscle strength, executive control function and depression test scores substantially attenuated these associations. INTERPRETATIONS: MTR in older adults may be an important additional marker of brain abnormalities associated with slower gait. Studies to explore the relationship between brain micro- and macrostructural abnormalities with gait and the role of mediating factors are warranted.
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1016/j.neurobiolaging.2008.08.004en
dc.subject.meshAgeden
dc.subject.meshAgingen
dc.subject.meshAtrophyen
dc.subject.meshBrainen
dc.subject.meshBrain Mappingen
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshGait Disorders, Neurologicen
dc.subject.meshHumansen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.subject.meshNerve Fibers, Myelinateden
dc.subject.meshNeurodegenerative Diseasesen
dc.subject.meshSex Characteristicsen
dc.titleMagnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and womenen
dc.typeArticleen
dc.contributor.departmentUniversity of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA. rosanoc@edc.pitt.eduen
dc.identifier.journalNeurobiology of agingen
html.description.abstractOBJECTIVE: To assess whether markers of micro- and macrostructural brain abnormalities are associated with slower gait in older men and women independent of each other, and also independent of health-related conditions and of behavioral, cognitive and peripheral function. METHODS: Magnetization transfer ratio [MTR], white matter hyperintensities [WMH], brain atrophy [BA] and brain infarcts [BI] were measured in 795 participants of the AGES-Reykjavik Study cohort (mean 75.6 years, 58.9% women). RESULTS: In women, lower MTR, higher WMH and BA, but not BI, remained associated with slower gait independent of each other and of other covariates. In men, WMH and BA, but not MTR or BI, remained associated with slower gait independently of each other. Only muscle strength, executive control function and depression test scores substantially attenuated these associations. INTERPRETATIONS: MTR in older adults may be an important additional marker of brain abnormalities associated with slower gait. Studies to explore the relationship between brain micro- and macrostructural abnormalities with gait and the role of mediating factors are warranted.


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