Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Wooster, RBignell, G
Lancaster, J
Swift, S
Seal, S
Mangion, J
Collins, N
Gregory, S
Gumbs, C
Micklem, G
Gudmundsson, J
Barkadottir, R B
Arason, A
Egilsson, V
Issue Date
1995-12-21
Metadata
Show full item recordCitation
Nature. 1995, 378(6559):789-92Abstract
In Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer cases, in particular those arising at a young age, are attributable to a highly penetrant, autosomal dominant predisposition to the disease. The breast cancer susceptibility gene, BRCA2, was recently localized to chromosome 13q12-q13. Here we report the identification of a gene in which we have detected six different germline mutations in breast cancer families that are likely to be due to BRCA2. Each mutation causes serious disruption to the open reading frame of the transcriptional unit. The results indicate that this is the BRCA2 gene.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1038/378789a0ae974a485f413a2113503eed53cd6c53
10.1038/378789a0
Scopus Count
Collections
Related articles
- Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene.
- Authors: Gayther SA, Mangion J, Russell P, Seal S, Barfoot R, Ponder BA, Stratton MR, Easton D
- Issue date: 1997 Jan
- BRCA2 germline mutations in male breast cancer cases and breast cancer families.
- Authors: Couch FJ, Farid LM, DeShano ML, Tavtigian SV, Calzone K, Campeau L, Peng Y, Bogden B, Chen Q, Neuhausen S, Shattuck-Eidens D, Godwin AK, Daly M, Radford DM, Sedlacek S, Rommens J, Simard J, Garber J, Merajver S, Weber BL
- Issue date: 1996 May
- Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12.
- Authors: Jacob AN, Kandpal G, Kandpal RP
- Issue date: 1996 Jul 4
- Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families.
- Authors: Phelan CM, Lancaster JM, Tonin P, Gumbs C, Cochran C, Carter R, Ghadirian P, Perret C, Moslehi R, Dion F, Faucher MC, Dole K, Karimi S, Foulkes W, Lounis H, Warner E, Goss P, Anderson D, Larsson C, Narod SA, Futreal PA
- Issue date: 1996 May
- BRCA2 germline mutations in Swedish breast cancer families.
- Authors: Chen J, Hedman MZ, Arver BW, Sigurdsson S, Eyfjörd JE, Lindblom A
- Issue date: 1998 Mar-Apr