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dc.contributor.authorOlafsdottir, Inga Sif
dc.contributor.authorJanson, Christer
dc.contributor.authorLind, Lars
dc.contributor.authorHulthe, Johannes
dc.contributor.authorGunnbjornsdottir, Maria
dc.contributor.authorSundström, Johan
dc.date.accessioned2011-01-10T15:29:38Z
dc.date.available2011-01-10T15:29:38Z
dc.date.issued2010-04-01
dc.date.submitted2011-01-10
dc.identifier.citationRespirology 2010, 15(3):530-5en
dc.identifier.issn1440-1843
dc.identifier.pmid20337997
dc.identifier.doi10.1111/j.1440-1843.2010.01718.x
dc.identifier.urihttp://hdl.handle.net/2336/119106
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMP) and their inhibitors, tissue inhibitors of metalloproteinases (TIMP), regulate homeostasis and turnover of the extra cellular matrix. The aim of this study was to investigate the associations of serum MMP-9 and TIMP-1 with lung function. METHODS: Spirometry was performed in a population-based sample of 888 subjects aged 70 years. Serum MMP-9 and TIMP-1 concentrations were measured by ELISA. RESULTS: Lower FEV(1) values were associated with higher serum levels of MMP-9 (P = 0.001) and TIMP-1 (P < 0.001), and a higher ratio of MMP-9 to TIMP-1 (P = 0.02). These associations were significant after adjustment for gender, weight, height, BMI, current smoking, pack years of smoking and the time for which samples were frozen. After stratification for gender, the associations between FEV(1) and MMP-9, TIMP-1, and their ratio, were significant in men but not in women. CONCLUSIONS: Lower FEV(1) was significantly but weakly associated with higher serum levels of MMP-9, TIMP-1 and a higher MMP-9/TIMP-1 ratio. This association was stronger in men than in women, suggesting a possible role for extracellular matrix remodelling in the development of impaired lung function. These associations may also partly explain the association between low FEV(1) and cardiovascular disease.
dc.language.isoenen
dc.publisherBlackwell Scienceen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1440-1843.2010.01718.xen
dc.subject.meshAgeden
dc.subject.meshAgingen
dc.subject.meshExtracellular Matrixen
dc.subject.meshFemaleen
dc.subject.meshForced Expiratory Volumeen
dc.subject.meshHumansen
dc.subject.meshLungen
dc.subject.meshMaleen
dc.subject.meshMatrix Metalloproteinase 9en
dc.subject.meshPredictive Value of Testsen
dc.subject.meshRegression Analysisen
dc.subject.meshRetrospective Studiesen
dc.subject.meshSex Characteristicsen
dc.subject.meshSpirometryen
dc.subject.meshTissue Inhibitor of Metalloproteinase-1en
dc.titleSerum levels of matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and their ratio are associated with impaired lung function in the elderly: a population-based studyen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Sciences: Respiratory Medicine & Allergology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. inga_sif.olafsdottir@medsci.uu.seen
dc.identifier.journalRespirology (Carlton, Vic.)en
html.description.abstractBACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMP) and their inhibitors, tissue inhibitors of metalloproteinases (TIMP), regulate homeostasis and turnover of the extra cellular matrix. The aim of this study was to investigate the associations of serum MMP-9 and TIMP-1 with lung function. METHODS: Spirometry was performed in a population-based sample of 888 subjects aged 70 years. Serum MMP-9 and TIMP-1 concentrations were measured by ELISA. RESULTS: Lower FEV(1) values were associated with higher serum levels of MMP-9 (P = 0.001) and TIMP-1 (P < 0.001), and a higher ratio of MMP-9 to TIMP-1 (P = 0.02). These associations were significant after adjustment for gender, weight, height, BMI, current smoking, pack years of smoking and the time for which samples were frozen. After stratification for gender, the associations between FEV(1) and MMP-9, TIMP-1, and their ratio, were significant in men but not in women. CONCLUSIONS: Lower FEV(1) was significantly but weakly associated with higher serum levels of MMP-9, TIMP-1 and a higher MMP-9/TIMP-1 ratio. This association was stronger in men than in women, suggesting a possible role for extracellular matrix remodelling in the development of impaired lung function. These associations may also partly explain the association between low FEV(1) and cardiovascular disease.


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