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Decreased bactericidal activity during the period of the postantibiotic effect

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Authors
Gudmundsson, S
Vogelman, B
Craig, W A
Issue Date
1994-12

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Citation
J. Antimicrob. Chemother. 1994, 34(6):921-30
Abstract
Standard and clinical strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae were subjected to continuous exposure to beta-lactams and aminoglycosides during the postantibiotic effect phase induced by rifampicin or erythromycin (for S. aureus). A significant inhibition of bactericidal activity by these agents during the PAE period was observed. The degree of inhibition was dependent both on the class of antimicrobial agent (beta-lactams > aminoglycosides) and the microorganism (Gram-negative bacilli > S. aureus).
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http://dx.doi.org/10.1093/jac/34.6.921
ae974a485f413a2113503eed53cd6c53
10.1093/jac/34.6.921
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English Journal Articles (Peer Reviewed)

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