Linkage analysis of 62 X-chromosomal loci excludes the X chromosome in an Icelandic family showing apparent X-linked recessive inheritance of neural tube defects
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Issue Date
1994-05
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Clin. Genet. 1994, 45(5):241-9Abstract
We report here the findings of a linkage analysis, involving numerous markers from the human X chromosome, in an attempt to localise a putative gene causing apparent X-linked spina bifida and anencephaly (SBA) in a large Icelandic pedigree. Two-point linkage analysis was performed using markers from 62 informative loci in this family. Although small positive lod scores were found at a number of these loci, none reached the significance level for linkage. Haplotypes were extensively analysed and found to exclude linkage to the X chromosome.Description
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http://dx.doi.org/10.1111/j.1399-0004.1994.tb04149.xae974a485f413a2113503eed53cd6c53
10.1111/j.1399-0004.1994.tb04149.x
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