Cord blood IgE levels are influenced by gestational age but do not predict allergic manifestations in infants
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationBlackwell Publishing. 1994, 5(1):5-10
AbstractThe predictive value of cord blood IgE (cIgE) for atopy and related disorders was investigated. Samples were collected from 792 infants delivered consecutively at the National University Hospital in Reykjavík in 1987. The concentration of IgE, but not that of IgA, was found to increase with increasing gestational age at birth. There was no correlation between IgE and IgA levels in individual samples. At the age of 18-23 months 180 of these children were studied for manifestations of allergy and related disorders. Included were all available infants with detectable (> or = 0.23 kU/L) cIgE. However, infants born by Cesarean section or with IgA exceeding 10 mg/L were excluded because of potential contamination with maternal blood. The clinical evaluation was made without knowledge of the IgE levels. Sixty-six of the 180 participants (36.6%) were judged to have had definite allergic manifestations. However, no striking correlation was found between allergic symptoms and cIgE levels in this study, nor did high levels of IgE add significantly to the predictive value of family history. Children with atopic features had more frequently been affected by otitis media. Unexpectedly, infants with intermediate cIgE levels (0.2-0.6 kU/L) were significantly less affected by otitis media than children with unmeasurable (< 0.2 kU/L) or high (> or = 0.7 kU/L) cIgE levels. It is concluded that cord blood IgE can not be used to predict allergic manifestations in children under the age of 2 years.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Prediction of atopy in the first year of life using cord blood IgE levels and family history.
- Authors: Sybilski AJ, Doboszynska A, Samolinski B
- Issue date: 2009 Dec 7
- Prediction of allergy from family history and cord blood IgE levels. A follow-up at the age of 5 years. Cord blood IgE. IV.
- Authors: Hansen LG, Halken S, Høst A, Møller K, Osterballe O
- Issue date: 1993 Feb
- Do parental smoking and history of allergy influence cord-serum IgE?
- Authors: Atici A, Altintaş D, Yüksel B, Evliyaoğlu N, Evrüke C, Satar M, Güneşer S
- Issue date: 1995 Nov
- Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants.
- Authors: Lúdvíksson BR, Eiríksson TH, Ardal B, Sigfússon A, Valdimarsson H
- Issue date: 1992 Jul
- Can family history and cord blood IgE predict sensitization and allergic diseases up to adulthood?
- Authors: Nissen SP, Kjaer HF, Høst A, Nielsen J, Halken S
- Issue date: 2015 Feb