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Renin gene restriction fragment length polymorphisms do not show linkage with preeclampsia and eclampsia

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Authors
Arngrimsson, R
Geirsson, R T
Cooke, A
Connor, M
Bjornsson, S
Walker, J J
Issue Date
1994-01

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Citation
Acta Obstet Gynecol Scand. 1994, 73(1):10-3
Abstract
OBJECTIVE: To investigate linkage between the renin gene restriction fragment length polymorphisms in families with a history of preeclampsia/eclampsia. METHODS: Nine Icelandic families with at least three affected females in two or three generations were investigated. DNA from lymphocytes was digested with the endonuclease restriction enzyme Bgl I and restriction fragments were transferred by Southern Blotting. Hybridisation was effected with the 32P-oligonucleotide-labeled diallelic genomic probe pHRnX 0.8. LOD scores were calculated by the Liped program for two forms of inheritance patterns. Affected sib pairs were analysed. RESULTS: Frequencies of the 9.0 kb and 5.0 kb alleles were 0.67 and 0.33, with no significant differences between affected females and spouses and combined LOD scores of -2 for recombination values of 3%. Allele sharing in affected sibs was not different from the expected random assortment. CONCLUSION: The linkage analysis provides evidence to exclude alteration of the renin gene in pregnancy as being directly responsible for the manifestations of preeclampsia or eclampsia in these families.
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http://dx.doi.org/10.3109/00016349409013385
ae974a485f413a2113503eed53cd6c53
10.3109/00016349409013385
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English Journal Articles (Peer Reviewed)

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