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dc.contributor.authorKalsi, G
dc.contributor.authorMankoo, B S
dc.contributor.authorBrynjolfsson, J
dc.contributor.authorCurtis, D
dc.contributor.authorRead, T
dc.contributor.authorMurphy, P
dc.contributor.authorSharma, T
dc.contributor.authorPetursson, H
dc.contributor.authorGurling, H M
dc.date.accessioned2011-02-28T11:25:46Z
dc.date.available2011-02-28T11:25:46Z
dc.date.issued1994
dc.date.submitted2011-02-28
dc.identifier.citationPsychiatr. Genet. 1994, 4(4):219-27en
dc.identifier.issn0955-8829
dc.identifier.pmid7712119
dc.identifier.urihttp://hdl.handle.net/2336/123054
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractMarfan syndrome (MS) is a rare autosomal dominant disorder of connective tissue with manifestations in the cardiovascular, ocular and skeletal systems. Genetic linkage analysis with random probes has mapped the MS locus to 15q21.1. There have been several reports of Marfan syndrome co-segregating with schizophrenia within families, which suggest that a common genetic factor may be shared between schizophrenia susceptibility and MS. This could be due to a cytogenetic abnormality affecting both genetic loci or due to co-segregation of two disease loci near each other on the same chromosome. We tested this hypothesis by using genetic linkage analysis with multiplex families. Using three genetic markers spanning the MS locus, we were unable to find evidence of linkage with schizophrenia across the Marfan syndrome locus on chromosome 15.
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://ovidsp.tx.ovid.com/sp-3.3.1a/ovidweb.cgi?&S=AJLKFPKHHADDEJGPNCCLIHDCKHEJAA00&Link+Set=S.sh.4796_1298892116_19.4796_1298892116_31.4796_1298892116_32.4796_1298892116_34.4796_1298892116_39.4796_1298892116_44%7c6%7csl_1226865en
dc.subject.meshChromosomes, Human, Pair 15en
dc.subject.meshDNAen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGreat Britainen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshMarfan Syndromeen
dc.subject.meshMicrofilament Proteinsen
dc.subject.meshPedigreeen
dc.subject.meshSchizophreniaen
dc.subject.meshSingle-Blind Methoden
dc.titleThe Marfan syndrome gene locus as a favoured locus for susceptibility to schizophreniaen
dc.typeArticleen
dc.contributor.departmentAcademic Department of Psychiatry, University College London Medical School, UK.en
dc.identifier.journalPsychiatric geneticsen
html.description.abstractMarfan syndrome (MS) is a rare autosomal dominant disorder of connective tissue with manifestations in the cardiovascular, ocular and skeletal systems. Genetic linkage analysis with random probes has mapped the MS locus to 15q21.1. There have been several reports of Marfan syndrome co-segregating with schizophrenia within families, which suggest that a common genetic factor may be shared between schizophrenia susceptibility and MS. This could be due to a cytogenetic abnormality affecting both genetic loci or due to co-segregation of two disease loci near each other on the same chromosome. We tested this hypothesis by using genetic linkage analysis with multiplex families. Using three genetic markers spanning the MS locus, we were unable to find evidence of linkage with schizophrenia across the Marfan syndrome locus on chromosome 15.


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