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Young maternal age at delivery is associated with asthma in adult offspring

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Authors
Laerum, Birger N
Svanes, Cecilie
Wentzel-Larsen, Tore
Gulsvik, Amund
Torén, Kjell
Norrman, Eva
Gislason, Thorarinn
Janson, Christer
Omenaas, Ernst
Issue Date
2007-07-01

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Respir Med 2007, 101(7):1431-8
Abstract
OBJECTIVE: Some studies have shown an association between lower maternal age at delivery and increased asthma in children and young adults. It is unclear whether this represents an effect of maternal ageing or a protective effect of siblings. In a North-European population based study, we investigated whether mother's age at delivery was associated with risk for asthma and hay fever in adult offspring, taking into account relevant confounders. METHODS: A total of 16,190 subjects (74%) aged 23-54yr answered a postal questionnaire in a follow-up of the European Community Respiratory Health Survey (ECRHS I). RESULTS: The associations of maternal age at delivery with hay fever, respiratory symptoms and diagnosed asthma were analysed using logistic regression, adjusting for household size, dwelling, parental education, centre, gender, adult hay fever, smoking, age and body mass index (BMI). The adjusted odds ratios (95% CI) for wheeze with breathlessness, wheeze without a cold and asthma in the offspring were 0.94 (0.90-0.99), 0.89 (0.86-0.94) and 0.92 (0.88-0.97), respectively, per 5yr increase in maternal age. No heterogeneity between centres was found (p=0.84). The estimates remained similar in sub-sample analyses when adjusting for siblings, maternal smoking (n=3109) and for birth weight (n=1686). Hay fever was more common among those with the youngest and oldest mothers. CONCLUSIONS: In this large North-European multi-centre study, asthma was less common with increasing maternal age. This effect was consistent between centres and persisted with adjustment for several potential confounders, suggesting that the association may possibly be explained by biological changes related to maternal ageing.
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http://www.sciencedirect.com/science/article/B6WWS-4N7RD47-1/2/1918d4d4e396bbbf0b9e810f8d8052e8
ae974a485f413a2113503eed53cd6c53
10.1016/j.rmed.2007.01.020
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