Young maternal age at delivery is associated with asthma in adult offspring
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsLaerum, Birger N
MetadataShow full item record
CitationRespir Med 2007, 101(7):1431-8
AbstractOBJECTIVE: Some studies have shown an association between lower maternal age at delivery and increased asthma in children and young adults. It is unclear whether this represents an effect of maternal ageing or a protective effect of siblings. In a North-European population based study, we investigated whether mother's age at delivery was associated with risk for asthma and hay fever in adult offspring, taking into account relevant confounders. METHODS: A total of 16,190 subjects (74%) aged 23-54yr answered a postal questionnaire in a follow-up of the European Community Respiratory Health Survey (ECRHS I). RESULTS: The associations of maternal age at delivery with hay fever, respiratory symptoms and diagnosed asthma were analysed using logistic regression, adjusting for household size, dwelling, parental education, centre, gender, adult hay fever, smoking, age and body mass index (BMI). The adjusted odds ratios (95% CI) for wheeze with breathlessness, wheeze without a cold and asthma in the offspring were 0.94 (0.90-0.99), 0.89 (0.86-0.94) and 0.92 (0.88-0.97), respectively, per 5yr increase in maternal age. No heterogeneity between centres was found (p=0.84). The estimates remained similar in sub-sample analyses when adjusting for siblings, maternal smoking (n=3109) and for birth weight (n=1686). Hay fever was more common among those with the youngest and oldest mothers. CONCLUSIONS: In this large North-European multi-centre study, asthma was less common with increasing maternal age. This effect was consistent between centres and persisted with adjustment for several potential confounders, suggesting that the association may possibly be explained by biological changes related to maternal ageing.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Relationship between early life respiratory illness, family size over time, and the development of asthma and hay fever: a seven year follow up study.
- Authors: Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A
- Issue date: 1999 Aug
- Early exposure to children in family and day care as related to adult asthma and hay fever: results from the European Community Respiratory Health Survey.
- Authors: Svanes C, Jarvis D, Chinn S, Omenaas E, Gulsvik A, Burney P, European Community Respiratory Health Survey.
- Issue date: 2002 Nov
- Relationship of fish and cod oil intake with adult asthma.
- Authors: Laerum BN, Wentzel-Larsen T, Gulsvik A, Omenaas E, Gíslason T, Janson C, Svanes C
- Issue date: 2007 Nov
- Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey.
- Authors: Svanes C, Heinrich J, Jarvis D, Chinn S, Omenaas E, Gulsvik A, Künzli N, Burney P
- Issue date: 2003 Aug
- Oral contraception, body mass index, and asthma: a cross-sectional Nordic-Baltic population survey.
- Authors: Macsali F, Real FG, Omenaas ER, Bjorge L, Janson C, Franklin K, Svanes C
- Issue date: 2009 Feb