A common variant on chromosome 9p21 affects the risk of myocardial infarction

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Authors
Helgadottir, Anna
Thorleifsson, Gudmar
Manolescu, Andrei
Gretarsdottir, Solveig
Blondal, Thorarinn
Jonasdottir, Aslaug
Jonasdottir, Adalbjorg
Sigurdsson, Asgeir
Baker, Adam
Palsson, Arnar
Masson, Gisli
Gudbjartsson, Daniel F
Magnusson, Kristinn P
Andersen, Karl
Levey, Allan I
Backman, Valgerdur M
Matthiasdottir, Sigurborg
Jonsdottir, Thorbjorg
Palsson, Stefan
Einarsdottir, Helga
Gunnarsdottir, Steinunn
Gylfason, Arnaldur
Vaccarino, Viola
Hooper, W Craig
Reilly, Muredach P
Granger, Christopher B
Austin, Harland
Rader, Daniel J
Shah, Svati H
Quyyumi, Arshed A
Gulcher, Jeffrey R
Thorgeirsson, Gudmundur
Thorsteinsdottir, Unnur
Kong, Augustine
Stefansson, Kari
Issue Date
2007-06-08

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Citation
Science 2007, 316(5830):1491-3
Abstract
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.
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http://www.sciencemag.org/cgi/content/full/316/5830/1491
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