A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Walters, G Bragi
Ng, Maggie C Y
Wilensky, Robert L
Reilly, Muredach P
Ma, Ronald C Y
van Vliet-Ostaptchouk, Jana V
Hofker, Marten H
Rader, Daniel J
Chan, Juliana C N
Gulcher, Jeffrey R
MetadataShow full item record
CitationNat. Genet. 2007, 39(6):770-5
AbstractWe conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk. In addition to confirming two recently identified risk variants, we identified a variant in the CDKAL1 gene that was associated with T2D in individuals of European ancestry (allele-specific odds ratio (OR) = 1.20 (95% confidence interval, 1.13-1.27), P = 7.7 x 10(-9)) and individuals from Hong Kong of Han Chinese ancestry (OR = 1.25 (1.11-1.40), P = 0.00018). The genotype OR of this variant suggested that the effect was substantially stronger in homozygous carriers than in heterozygous carriers. The ORs for homozygotes were 1.50 (1.31-1.72) and 1.55 (1.23-1.95) in the European and Hong Kong groups, respectively. The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link
- Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
- Authors: Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR
- Issue date: 2006 Sep
- Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.
- Authors: Ng MC, Tam CH, Lam VK, So WY, Ma RC, Chan JC
- Issue date: 2007 Sep
- Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.
- Authors: Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA
- Issue date: 2007 Aug
- TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
- Authors: Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D, Diabetes Prevention Program Research Group.
- Issue date: 2006 Jul 20
- TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women.
- Authors: Cornelis MC, Qi L, Kraft P, Hu FB
- Issue date: 2009 Apr