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dc.contributor.authorOlafsdottir, Linda Bjork
dc.contributor.authorGudjonsson, Hallgrimur
dc.contributor.authorJonsdottir, Heidur Hrund
dc.contributor.authorThjodleifsson, Bjarni
dc.date.accessioned2011-03-21T09:37:33Z
dc.date.available2011-03-21T09:37:33Z
dc.date.issued2010
dc.date.submitted2011-03-21
dc.identifier.citationDigestion. 2010, 81(1):53-61en
dc.identifier.issn1421-9867
dc.identifier.pmid20029209
dc.identifier.doi10.1159/000243783
dc.identifier.urihttp://hdl.handle.net/2336/125128
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited. AIM: To study the natural history of FD as assessed by 2 criteria over a 10-year period. METHOD: A population-based study conducted by mailing a questionnaire to the same age- and gender-stratified random sample of the Icelandic population aged 18-75 in 1996 and again in 2006. FD was estimated by the Functional Dyspepsia Score List and by dyspepsia subgroups categorized into 4 groups: (1) frequent upper pain, (2) meal-related, (3) nausea or vomiting, and (4) combinations of these groups. Results: FD was diagnosed in 13.9% of the subjects in the 1996 sample (11.3% male, 15.8% female) and 16.7% in 2006 (12.3% male, 20.2% female) with a significant difference between males and females in 2006. Dyspepsia subgroup criteria showed a higher prevalence than conventional FD criteria. The proportion of FD subjects in one of the dyspepsia subgroups was low. There was a significant relationship between FD and heartburn and irritable bowel syndrome. A high proportion of subjects who seek medical care have FD. CONCLUSION: FD was stable over the 10-year period, but there was turnover in symptoms and increased intensity and frequency of gastrointestinal pain. Dyspepsia subgroup criteria showed a higher prevalence than FD, which was more common in young subjects and females. FD poses a heavy burden on the health care system.
dc.language.isoenen
dc.publisherKrageren
dc.relation.urlhttp://dx.doi.org/10.1159/000243783en
dc.subject.meshAdulten
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAlcohol Drinkingen
dc.subject.meshBody Mass Indexen
dc.subject.meshBody Weighten
dc.subject.meshDyspepsiaen
dc.subject.meshFemaleen
dc.subject.meshHeartburnen
dc.subject.meshHumansen
dc.subject.meshIrritable Bowel Syndromeen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPainen
dc.subject.meshPrevalenceen
dc.subject.meshQuestionnairesen
dc.subject.meshSex Distributionen
dc.subject.meshSmokingen
dc.titleNatural history of functional dyspepsia: a 10-year population-based studyen
dc.typeArticleen
dc.contributor.departmentDepartment of Gastroenterology, Landspitali-University Hospital, Reykjavik, Iceland. linda04@ru.isen
dc.identifier.journalDigestionen
html.description.abstractBACKGROUND: Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited. AIM: To study the natural history of FD as assessed by 2 criteria over a 10-year period. METHOD: A population-based study conducted by mailing a questionnaire to the same age- and gender-stratified random sample of the Icelandic population aged 18-75 in 1996 and again in 2006. FD was estimated by the Functional Dyspepsia Score List and by dyspepsia subgroups categorized into 4 groups: (1) frequent upper pain, (2) meal-related, (3) nausea or vomiting, and (4) combinations of these groups. Results: FD was diagnosed in 13.9% of the subjects in the 1996 sample (11.3% male, 15.8% female) and 16.7% in 2006 (12.3% male, 20.2% female) with a significant difference between males and females in 2006. Dyspepsia subgroup criteria showed a higher prevalence than conventional FD criteria. The proportion of FD subjects in one of the dyspepsia subgroups was low. There was a significant relationship between FD and heartburn and irritable bowel syndrome. A high proportion of subjects who seek medical care have FD. CONCLUSION: FD was stable over the 10-year period, but there was turnover in symptoms and increased intensity and frequency of gastrointestinal pain. Dyspepsia subgroup criteria showed a higher prevalence than FD, which was more common in young subjects and females. FD poses a heavy burden on the health care system.


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