Decreasing case fatality in myocardial infarction is explained by improved medical treatment

Abstract

Objective Treatment of ST-elevation myocardial infarction (STEMI) has changed signifi cantly over the past two decades. We investigated the eff ect of these changes on one-year mortality. Methods and results All hospital admissions for STEMI in Reykjavik, Iceland, during the calendar years of 1986, 1996 and 2006 were studied. One-year mortality was related to changes in the use of reperfusion strategies and medication at hospital discharge. One-year mortality decreased from 26.3% in 1986 and 19.7% in 1996 to 12.9% in 2006 (P = 0.001). Cox proportional hazard analysis showed that aspirin (HR 0.29), the use of reperfusion therapy (HR 0.51) and beta-blockers at hospital discharge (HR 0.53) were the strongest factors to explain the mortality reduction while the use of diuretics (HR 1.42) and age (HR 1.06) were related to increased one-year mortality. Conclusions The reduction in one-year mortality after myocardial infarction during the last two decades is explained by improved medical management with aspirin, beta-blockers and aggressive reperfusion therapy. Diuretic therapy, refl ecting congestive heart failure, and increased age have negative eff ects on survival.