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dc.contributor.authorBenediktsdottir, Bryndis
dc.contributor.authorJanson, Christer
dc.contributor.authorLindberg, Eva
dc.contributor.authorArnardóttir, Erna Sif
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorCook, Elizabeth
dc.contributor.authorThorarinsdottir, Elin Helga
dc.contributor.authorGislason, Thorarinn
dc.date.accessioned2011-03-24T11:47:31Z
dc.date.available2011-03-24T11:47:31Z
dc.date.issued2010-12
dc.date.submitted2011-03
dc.identifier.citationSleep Med. 2010, 11(10):1043-8en
dc.identifier.issn1878-5506
dc.identifier.pmid20961808
dc.identifier.doi10.1016/j.sleep.2010.08.006
dc.identifier.urihttp://hdl.handle.net/2336/125513
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and Uppsala, Sweden. METHODS: Using the national registries of inhabitants, a random sample from adults aged 40 and over living in Reykjavík, Iceland (n=939), and Uppsala, Sweden (n=998), were invited to participate in a study on the prevalence of COPD (response rate 81.1% and 62.2%). In addition, the participants were asked to answer the following questionnaires: International RLS Rating Scale, Short Form-12, the Epworth Sleepiness Scale, and questions about sleep, gastroeosophageal reflux, diabetes and hypertension, as well as pharmacological treatment. Interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin were measured in serum. RESULTS: RLS was more commonly reported in Reykjavik (18.3%) than in Uppsala (11.5%). Icelandic women reported RLS almost twice as often as Swedish women (24.4 vs. 13.9% p=0.001), but there was no difference in prevalence of RLS between Icelandic and Swedish men. RLS was strongly associated with sleep disturbances and excessive daytime sleepiness. Subjects with RLS were more likely to be ex- and current smokers than subjects without RLS (p<0.001). Respiratory symptoms and airway obstruction were more prevalent among those reporting RLS and they also estimated their physical quality of life lower than those without RLS (p<0.001). RLS was not associated with symptoms of the metabolic syndrome like hypertension, obesity, markers of systemic inflammation (IL-6 and CRP) or cardiovascular diseases. Ferritin levels were significantly lower in RLS participants (p=0.0002), but not (p=0.07) after adjustment for center, age, sex and smoking history. CONCLUSION: Restless legs syndrome was twice as common among Icelandic women compared to Swedish women. No such difference was seen for men. RLS was strongly associated with smoking and respiratory symptoms, decreased lung function, sleep disturbances, excessive daytime sleepiness, and physical aspects of life quality. RLS was not associated with markers of the metabolic syndrome like hypertension, obesity, cardiovascular diseases or biomarkers of systemic inflammation.
dc.language.isoenen
dc.publisherElsiver Sciencsen
dc.relation.urlhttp://dx.doi.org/10.1016/j.sleep.2010.08.006en
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshBiological Markersen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshComorbidityen
dc.subject.meshFemaleen
dc.subject.meshFerritinsen
dc.subject.meshHumansen
dc.subject.meshHypertensionen
dc.subject.meshIcelanden
dc.subject.meshInflammationen
dc.subject.meshInterleukin-6en
dc.subject.meshLung Diseasesen
dc.subject.meshMaleen
dc.subject.meshMetabolic Syndrome Xen
dc.subject.meshMiddle Ageden
dc.subject.meshPrevalenceen
dc.subject.meshQuality of Lifeen
dc.subject.meshRestless Legs Syndromeen
dc.subject.meshSmokingen
dc.subject.meshSpirometryen
dc.subject.meshSwedenen
dc.titlePrevalence of restless legs syndrome among adults in Iceland and Sweden: Lung function, comorbidity, ferritin, biomarkers and quality of lifeen
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, University of Iceland, Iceland.en
dc.identifier.journalSleep medicineen
html.description.abstractOBJECTIVE: This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and Uppsala, Sweden. METHODS: Using the national registries of inhabitants, a random sample from adults aged 40 and over living in Reykjavík, Iceland (n=939), and Uppsala, Sweden (n=998), were invited to participate in a study on the prevalence of COPD (response rate 81.1% and 62.2%). In addition, the participants were asked to answer the following questionnaires: International RLS Rating Scale, Short Form-12, the Epworth Sleepiness Scale, and questions about sleep, gastroeosophageal reflux, diabetes and hypertension, as well as pharmacological treatment. Interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin were measured in serum. RESULTS: RLS was more commonly reported in Reykjavik (18.3%) than in Uppsala (11.5%). Icelandic women reported RLS almost twice as often as Swedish women (24.4 vs. 13.9% p=0.001), but there was no difference in prevalence of RLS between Icelandic and Swedish men. RLS was strongly associated with sleep disturbances and excessive daytime sleepiness. Subjects with RLS were more likely to be ex- and current smokers than subjects without RLS (p<0.001). Respiratory symptoms and airway obstruction were more prevalent among those reporting RLS and they also estimated their physical quality of life lower than those without RLS (p<0.001). RLS was not associated with symptoms of the metabolic syndrome like hypertension, obesity, markers of systemic inflammation (IL-6 and CRP) or cardiovascular diseases. Ferritin levels were significantly lower in RLS participants (p=0.0002), but not (p=0.07) after adjustment for center, age, sex and smoking history. CONCLUSION: Restless legs syndrome was twice as common among Icelandic women compared to Swedish women. No such difference was seen for men. RLS was strongly associated with smoking and respiratory symptoms, decreased lung function, sleep disturbances, excessive daytime sleepiness, and physical aspects of life quality. RLS was not associated with markers of the metabolic syndrome like hypertension, obesity, cardiovascular diseases or biomarkers of systemic inflammation.


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