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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

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Authors
Voight, Benjamin F
Scott, Laura J
Steinthorsdottir, Valgerdur
Morris, Andrew P
Dina, Christian
Welch, Ryan P
Zeggini, Eleftheria
Huth, Cornelia
Aulchenko, Yurii S
Thorleifsson, Gudmar
McCulloch, Laura J
Ferreira, Teresa
Grallert, Harald
Amin, Najaf
Wu, Guanming
Willer, Cristen J
Raychaudhuri, Soumya
McCarroll, Steve A
Langenberg, Claudia
Hofmann, Oliver M
Dupuis, Josée
Qi, Lu
Segrè, Ayellet V
van Hoek, Mandy
Navarro, Pau
Ardlie, Kristin
Balkau, Beverley
Benediktsson, Rafn
Bennett, Amanda J
Blagieva, Roza
Boerwinkle, Eric
Bonnycastle, Lori L
Bengtsson Boström, Kristina
Bravenboer, Bert
Bumpstead, Suzannah
Burtt, Noisël P
Charpentier, Guillaume
Chines, Peter S
Cornelis, Marilyn
Couper, David J
Crawford, Gabe
Doney, Alex S F
Elliott, Katherine S
Elliott, Amanda L
Erdos, Michael R
Fox, Caroline S
Franklin, Christopher S
Ganser, Martha
Gieger, Christian
Grarup, Niels
Green, Todd
Griffin, Simon
Groves, Christopher J
Guiducci, Candace
Hadjadj, Samy
Hassanali, Neelam
Herder, Christian
Isomaa, Bo
Jackson, Anne U
Johnson, Paul R V
Jørgensen, Torben
Kao, Wen H L
Klopp, Norman
Kong, Augustine
Kraft, Peter
Kuusisto, Johanna
Lauritzen, Torsten
Li, Man
Lieverse, Aloysius
Lindgren, Cecilia M
Lyssenko, Valeriya
Marre, Michel
Meitinger, Thomas
Midthjell, Kristian
Morken, Mario A
Narisu, Narisu
Nilsson, Peter
Owen, Katharine R
Payne, Felicity
Perry, John R B
Petersen, Ann-Kristin
Platou, Carl
Proença, Christine
Prokopenko, Inga
Rathmann, Wolfgang
Rayner, N William
Robertson, Neil R
Rocheleau, Ghislain
Roden, Michael
Sampson, Michael J
Saxena, Richa
Shields, Beverley M
Shrader, Peter
Sigurdsson, Gunnar
Sparsø, Thomas
Strassburger, Klaus
Stringham, Heather M
Sun, Qi
Swift, Amy J
Thorand, Barbara
Tichet, Jean
Tuomi, Tiinamaija
van Dam, Rob M
van Haeften, Timon W
van Herpt, Thijs
van Vliet-Ostaptchouk, Jana V
Walters, G Bragi
Weedon, Michael N
Wijmenga, Cisca
Witteman, Jacqueline
Bergman, Richard N
Cauchi, Stephane
Collins, Francis S
Gloyn, Anna L
Gyllensten, Ulf
Hansen, Torben
Hide, Winston A
Hitman, Graham A
Hofman, Albert
Hunter, David J
Hveem, Kristian
Laakso, Markku
Mohlke, Karen L
Morris, Andrew D
Palmer, Colin N A
Pramstaller, Peter P
Rudan, Igor
Sijbrands, Eric
Stein, Lincoln D
Tuomilehto, Jaakko
Uitterlinden, Andre
Walker, Mark
Wareham, Nicholas J
Watanabe, Richard M
Abecasis, Gonçalo R
Boehm, Bernhard O
Campbell, Harry
Daly, Mark J
Hattersley, Andrew T
Hu, Frank B
Meigs, James B
Pankow, James S
Pedersen, Oluf
Wichmann, H-Erich
Barroso, Inês
Florez, Jose C
Frayling, Timothy M
Groop, Leif
Sladek, Rob
Thorsteinsdottir, Unnur
Wilson, James F
Illig, Thomas
Froguel, Philippe
van Duijn, Cornelia M
Stefansson, Kari
Altshuler, David
Boehnke, Michael
McCarthy, Mark I
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Issue Date
2010-07

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Citation
.Nat. Genet. 2010, 42(7):579-89
Abstract
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
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Additional Links
http://dx.doi.org/10.1038/ng.609
ae974a485f413a2113503eed53cd6c53
10.1038/ng.609
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