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dc.contributor.authorTreeprasertsuk, S
dc.contributor.authorHuntrakul, J
dc.contributor.authorRidtitid, W
dc.contributor.authorKullavanijaya, P
dc.contributor.authorBjornsson, E S
dc.date.accessioned2011-03-25T13:55:53Z
dc.date.available2011-03-25T13:55:53Z
dc.date.issued2010-06
dc.date.submitted2011-03-25
dc.identifier.citationAliment. Pharmacol. Ther. 2010, 31(11):1200-7en
dc.identifier.issn1365-2036
dc.identifier.pmid20222907
dc.identifier.doi10.1111/j.1365-2036.2010.04292.x
dc.identifier.urihttp://hdl.handle.net/2336/125673
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Antimicrobials are the leading cause of idiosyncratic drug-induced liver injury in most series. AIM: To determine the incidence and the predictors of complications in patients with drug-induced liver injury caused by antimicrobial agents requiring hospitalization. METHODS: Medical records of patients with drug-induced liver injury caused by antimicrobial agents were identified by ICD-10, for the period between 2002 and 2006. Clinical information and blood tests during hospitalization were recorded. The causality assessment of drug-induced liver injury was determined by the Roussel UCLAF causality assessment method (RUCAM) scale. RESULTS: Of 47 594 in-patient admissions per year, the annual incidence of drug-induced liver injury was 0.03%. Male: female ratio was 7:3 with a median age of 47 years. Eighty reactions of drug-induced liver injury were caused by anti-tuberculosis drugs (85%) and by antibiotics (15%). The median (IQR) of RUCAM scale was 6 (5-8). A total of 36% had HIV infection and 9% of patients had diabetes mellitus. Median (IQR) duration of hospitalization was 9 (5-15) days. Serious complications and death were found in 27.5% and 26%, respectively. By a multivariable logistic analysis, the presence of jaundice was found to be significantly associated with an unfavourable outcome. CONCLUSION: Although rare, antimicrobial agents-related drug-induced liver injury requiring hospitalization has a high mortality rate. The presence of jaundice predicts poor outcome.
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1365-2036.2010.04292.xen
dc.subject.meshAdulten
dc.subject.meshAnti-Infective Agentsen
dc.subject.meshDrug-Induced Liver Injuryen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshJaundiceen
dc.subject.meshLiveren
dc.subject.meshLiver Function Testsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPrognosisen
dc.subject.meshRetrospective Studiesen
dc.titleThe predictors of complications in patients with drug-induced liver injury caused by antimicrobial agentsen
dc.typeArticleen
dc.contributor.departmentChulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. battan5410@yahoo.com <battan5410@yahoo.com>en
dc.identifier.journalAlimentary pharmacology & therapeuticsen
html.description.abstractBACKGROUND: Antimicrobials are the leading cause of idiosyncratic drug-induced liver injury in most series. AIM: To determine the incidence and the predictors of complications in patients with drug-induced liver injury caused by antimicrobial agents requiring hospitalization. METHODS: Medical records of patients with drug-induced liver injury caused by antimicrobial agents were identified by ICD-10, for the period between 2002 and 2006. Clinical information and blood tests during hospitalization were recorded. The causality assessment of drug-induced liver injury was determined by the Roussel UCLAF causality assessment method (RUCAM) scale. RESULTS: Of 47 594 in-patient admissions per year, the annual incidence of drug-induced liver injury was 0.03%. Male: female ratio was 7:3 with a median age of 47 years. Eighty reactions of drug-induced liver injury were caused by anti-tuberculosis drugs (85%) and by antibiotics (15%). The median (IQR) of RUCAM scale was 6 (5-8). A total of 36% had HIV infection and 9% of patients had diabetes mellitus. Median (IQR) duration of hospitalization was 9 (5-15) days. Serious complications and death were found in 27.5% and 26%, respectively. By a multivariable logistic analysis, the presence of jaundice was found to be significantly associated with an unfavourable outcome. CONCLUSION: Although rare, antimicrobial agents-related drug-induced liver injury requiring hospitalization has a high mortality rate. The presence of jaundice predicts poor outcome.


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