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Thorleifsdottir, Ragna H
Sigurdardottir, Sigrun L
Gudjonsson, Johann E
MetadataShow full item record
CitationTrends Immunol. 2009, 30(10):494-501
AbstractPsoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.
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- Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells.
- Authors: Johnston A, Gudjonsson JE, Sigmundsdottir H, Love TJ, Valdimarsson H
- Issue date: 2004 Oct
- Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin?
- Authors: Valdimarsson H, Sigmundsdóttir H, Jónsdóttir I
- Issue date: 1997 Jan
- Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.
- Authors: Besgen P, Trommler P, Vollmer S, Prinz JC
- Issue date: 2010 May 1
- Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants.
- Authors: Thorleifsdottir RH, Sigurdardottir SL, Sigurgeirsson B, Olafsson JH, Sigurdsson MI, Petersen H, Arnadottir S, Gudjonsson JE, Johnston A, Valdimarsson H
- Issue date: 2012 May 15
- Peripheral blood mononuclear cells proliferation and Th1/Th2 cytokine production in response to streptococcal M protein in psoriatic patients.
- Authors: Pérez-Lorenzo R, Núñez-Oreza LA, Garma-Quen PM, López-Pacheco E, Bricaire-Bricaire G
- Issue date: 2006 May