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Psoriasis - as an autoimmune disease caused by molecular mimicry

dc.contributor.authorValdimarsson, Helgi
dc.contributor.authorThorleifsdottir, Ragna H
dc.contributor.authorSigurdardottir, Sigrun L
dc.contributor.authorGudjonsson, Johann E
dc.contributor.authorJohnston, Andrew
dc.date.accessioned2011-03-29T14:27:40Z
dc.date.available2011-03-29T14:27:40Z
dc.date.issued2009-10
dc.date.submitted2011-03-29
dc.identifier.citationTrends Immunol. 2009, 30(10):494-501en
dc.identifier.issn1471-4981
dc.identifier.pmid19781993
dc.identifier.doi10.1016/j.it.2009.07.008
dc.identifier.urihttp://hdl.handle.net/2336/126113
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.
dc.language.isoenen
dc.publisherElsiver Sciencsen
dc.relation.urlhttp://dx.doi.org/10.1016/j.it.2009.07.008en
dc.subject.meshAntigens, Bacterialen
dc.subject.meshAutoimmune Diseasesen
dc.subject.meshBacterial Outer Membrane Proteinsen
dc.subject.meshCD4-Positive T-Lymphocytesen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshCarrier Proteinsen
dc.subject.meshDermisen
dc.subject.meshEpidermisen
dc.subject.meshHumansen
dc.subject.meshKeratinsen
dc.subject.meshMolecular Mimicryen
dc.subject.meshPalatine Tonsilen
dc.subject.meshPeptidoglycanen
dc.subject.meshPsoriasisen
dc.subject.meshStreptococcal Infectionsen
dc.subject.meshStreptococcusen
dc.subject.meshSuperantigensen
dc.subject.meshTonsillitisen
dc.titlePsoriasis - as an autoimmune disease caused by molecular mimicryen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspitali University Hospital, Reykjavik, Iceland. helgiv@landspitali.isen
dc.identifier.journalTrends in immunologyen
html.description.abstractPsoriasis is strongly associated with streptococcal throat infection, and patients have increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells recognizing determinants common to streptococcal M-protein and keratin have been detected in patients' blood. We propose that CD8(+) T cells in psoriatic epidermis respond mainly to such determinants, whereas CD4(+) T cells in the dermis preferentially recognize determinants on the streptococcal peptidoglycan that might itself act as an adjuvant. The streptococcal association might reflect the concurrence of superantigen production promoting skin-homing of tonsil T cells, M-protein mimicking keratin determinants, and adjuvant effects of the peptidoglycan. Accordingly, improvement of psoriasis after tonsillectomy should be associated with fewer T cells that recognize keratin and streptococcal determinants.


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