Show simple item record

dc.contributor.authorMcAreavey, Dorotheaen
dc.contributor.authorVidal, Jean-Sébastienen
dc.contributor.authorAspelund, Thoren
dc.contributor.authorOwens, David Sen
dc.contributor.authorHughes, Timothyen
dc.contributor.authorGarcia, Melissaen
dc.contributor.authorSigurdsson, Sigurduren
dc.contributor.authorBjornsdottir, Halldoraen
dc.contributor.authorHarris, Tamara Ben
dc.contributor.authorGudnason, Vilmunduren
dc.contributor.authorLauner, Lenore Jen
dc.contributor.authorPlehn, Jonathan Fen
dc.date.accessioned2011-04-27T11:36:53Z
dc.date.available2011-04-27T11:36:53Z
dc.date.issued2010-10
dc.date.submitted2011-04-27
dc.identifier.citationStroke. 2010, 41(10):2223-8en
dc.identifier.issn1524-4628
dc.identifier.pmid20798368
dc.identifier.doi10.1161/STROKEAHA.110.590430
dc.identifier.urihttp://hdl.handle.net/2336/128760
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND AND PURPOSE: Chronic effects of hypertension may be observed in multiple end organs. Previous reports suggest that cardiovascular morphological features can mirror cerebral infarction. In this cross-sectional analysis of elderly subjects, we investigated the relationship of a comprehensive set of echocardiographic measures with cerebral infarction detected by MRI. METHODS: We compared echocardiographically determined left ventricular (LV) mass, left atrial volume, aortic root diameter, mitral annular calcification, and measures of diastolic function with cerebral infarction determined by MRI using logistic regression in a random sample drawn from the Age Gene/Environment Susceptibility-Reykjavik Study cohort. The model was first adjusted for age and gender, and then for age, gender, and vascular risk factors. RESULTS: Among 692 subjects aged 75 (standard deviation, 6) years, 28% had at least 1 cerebral infarct. When adjusted for age and gender, the presence of cerebral infarction was modestly related to LV mass (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.00-1.02) and left atrial volume (OR, 1.03; 95% CI, 1.01-1.05), as well as the lowest quartile of early-to-late pulsed Doppler velocity ratio (early-to-late pulsed Doppler velocity ratio <0.75; OR, 1.87; 95% CI, 1.22-2.87). The latter relation remained significant after adjustment for vascular risk factors and LV ejection fraction (OR, 1.82; 95% CI, 1.16-2.86). CONCLUSIONS: Of all echocardiographic parameters, LV filling abnormality as indicated by low early-to-late pulsed Doppler velocity ratio displayed the strongest association with cerebral infarction and this relationship was independent of vascular risk factors. This simple marker of cerebral infarction may be useful when evaluating older patients.
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1161/STROKEAHA.110.590430en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshBlood Flow Velocityen
dc.subject.meshCerebral Infarctionen
dc.subject.meshCohort Studiesen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshEchocardiographyen
dc.subject.meshFemaleen
dc.subject.meshHeart Atriaen
dc.subject.meshHumansen
dc.subject.meshHypertensionen
dc.subject.meshLogistic Modelsen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.subject.meshOdds Ratioen
dc.subject.meshRisk Factorsen
dc.subject.meshVentricular Dysfunction, Leften
dc.titleCorrelation of echocardiographic findings with cerebral infarction in elderly adults: the AGES-Reykjavik studyen
dc.typeArticleen
dc.contributor.departmentNIH Clinical Center, National Institutes of Health, Bethesda, Md, USA. dmcareavey@cc.nih.goven
dc.identifier.journalStroke; a journal of cerebral circulationen
html.description.abstractBACKGROUND AND PURPOSE: Chronic effects of hypertension may be observed in multiple end organs. Previous reports suggest that cardiovascular morphological features can mirror cerebral infarction. In this cross-sectional analysis of elderly subjects, we investigated the relationship of a comprehensive set of echocardiographic measures with cerebral infarction detected by MRI. METHODS: We compared echocardiographically determined left ventricular (LV) mass, left atrial volume, aortic root diameter, mitral annular calcification, and measures of diastolic function with cerebral infarction determined by MRI using logistic regression in a random sample drawn from the Age Gene/Environment Susceptibility-Reykjavik Study cohort. The model was first adjusted for age and gender, and then for age, gender, and vascular risk factors. RESULTS: Among 692 subjects aged 75 (standard deviation, 6) years, 28% had at least 1 cerebral infarct. When adjusted for age and gender, the presence of cerebral infarction was modestly related to LV mass (odds ratio [OR], 1.01; 95% confidence interval [CI], 1.00-1.02) and left atrial volume (OR, 1.03; 95% CI, 1.01-1.05), as well as the lowest quartile of early-to-late pulsed Doppler velocity ratio (early-to-late pulsed Doppler velocity ratio <0.75; OR, 1.87; 95% CI, 1.22-2.87). The latter relation remained significant after adjustment for vascular risk factors and LV ejection fraction (OR, 1.82; 95% CI, 1.16-2.86). CONCLUSIONS: Of all echocardiographic parameters, LV filling abnormality as indicated by low early-to-late pulsed Doppler velocity ratio displayed the strongest association with cerebral infarction and this relationship was independent of vascular risk factors. This simple marker of cerebral infarction may be useful when evaluating older patients.


This item appears in the following Collection(s)

Show simple item record