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dc.contributor.authorJonsson, Helgi
dc.contributor.authorHelgadottir, Gudrun P
dc.contributor.authorAspelund, Thor
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorSiggeirsdottir, Kristin
dc.contributor.authorIngvarsson, Thorvaldur
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore
dc.contributor.authorGudnason, Vilmundur
dc.date.accessioned2011-05-06T09:39:27Z
dc.date.available2011-05-06T09:39:27Z
dc.date.issued2011-06
dc.date.submitted2011-05-06
dc.identifier.citationAnn. Rheum. Dis. 2011, 70(6):1087-90en
dc.identifier.issn1468-2060
dc.identifier.pmid21367759
dc.identifier.doi10.1136/ard.2010.144980
dc.identifier.urihttp://hdl.handle.net/2336/129194
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: /st> This study examines the relationship between total knee replacements (TKR), total hip replacements (THR) or replacements of either joint (total joint replacement; TJR) due to osteoarthritis and atherosclerosis in a large population-based study. METHODS: /st> The participants were 2195 men and 2975 women, mean age 76±6 years. The osteoarthritis data were analysed in relation to measures of atherosclerosis, including carotid artery intima media thickness and plaque severity (ultrasound), coronary and aortic calcifications (CT), cerebral white matter lesions (MRI) and a history of previous cardiac and cerebral events. RESULTS: /st> The prevalence of TKR was 223 (4.3%) and THR 316 (6.1%). The presence of TJR in women was associated with a non-significant trend towards increased carotid plaque severity, coronary calcifications and periventricular white matter hyperintensities (PVH) but not with a history of cardiac or cerebral events. No associations were seen in men. When TJR were grouped according to the presence or absence of hand osteoarthritis (HOA) there was a highly significant association in the order -TJR/-HOA < +TJR/-HOA < -TJR/+HOA < +TJR/+HOA, for carotid plaque severity, coronary calcifications and PVH. CONCLUSION: /st> The presence of TJR did not show a significant independent association with atherosclerosis but enhanced the strength of the positive association between HOA and subclinical atherosclerosis in women.
dc.language.isoenen
dc.publisherBMJen
dc.relation.urlhttp://dx.doi.org/10.1136/ard.2010.144980en
dc.subject.meshPubMed in processen
dc.subject.meshAtherosclerosisen
dc.subject.meshOsteoarthritisen
dc.subject.meshFemaleen
dc.titleThe presence of total knee or hip replacements due to osteoarthritis enhances the positive association between hand osteoarthritis and atherosclerosis in women: the AGES-Reykjavik studyen
dc.typeArticleen
dc.contributor.departmentCorrespondence to Professor Helgi Jonsson, Landspitalinn University Hospital, University of Iceland, IS-108 Fossvogur, Reykjavik, Iceland; helgi@hi.is.en
dc.identifier.journalAnnals of the rheumatic diseasesen
html.description.abstractOBJECTIVE: /st> This study examines the relationship between total knee replacements (TKR), total hip replacements (THR) or replacements of either joint (total joint replacement; TJR) due to osteoarthritis and atherosclerosis in a large population-based study. METHODS: /st> The participants were 2195 men and 2975 women, mean age 76±6 years. The osteoarthritis data were analysed in relation to measures of atherosclerosis, including carotid artery intima media thickness and plaque severity (ultrasound), coronary and aortic calcifications (CT), cerebral white matter lesions (MRI) and a history of previous cardiac and cerebral events. RESULTS: /st> The prevalence of TKR was 223 (4.3%) and THR 316 (6.1%). The presence of TJR in women was associated with a non-significant trend towards increased carotid plaque severity, coronary calcifications and periventricular white matter hyperintensities (PVH) but not with a history of cardiac or cerebral events. No associations were seen in men. When TJR were grouped according to the presence or absence of hand osteoarthritis (HOA) there was a highly significant association in the order -TJR/-HOA < +TJR/-HOA < -TJR/+HOA < +TJR/+HOA, for carotid plaque severity, coronary calcifications and PVH. CONCLUSION: /st> The presence of TJR did not show a significant independent association with atherosclerosis but enhanced the strength of the positive association between HOA and subclinical atherosclerosis in women.


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