• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • Icelandic Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • Icelandic Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Talídómíð, lyf hörmunga og hjálpræðis : yfirlitsgrein : tilurð talídómíðs, sameindargerð og fyrsti ferill

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
L2003-10-98-F1.pdf
Size:
236.8Kb
Format:
PDF
Description:
Allur texti - Full Text
Download
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Þorkell Jóhannesson
Issue Date
2003-10-01

Metadata
Show full item record
Other Titles
Thalidomide: Drug of horror and last resort. A review. Part 1: Origin, molecular structure and first pattern of use
Citation
Læknablaðið 2003, 89(10):751-756
Abstract
Thalidomide was originally a hypnotic, sedative and anxiolytic drug that was first used in 1955. It was considered to have little toxicity and have smooth activity. Thalidomide was in fact poorly studied both in animals and for therapeutic purposes. It was nevertheless agressively advertised, and inter alia for use in pregnancy, and accordingly it was a much used drug. During the year 1961 it became evident that intake of thalidomide in therapeutic doses could result in severe peripheral neuritis and, when taken early in pregnancy, in horrendous damage to the fetus. Thalidomide was thus shortly afterwards generally removed from the market and its use prohibited. Nevertheless, interest rose a few years later to use thalidomide on other indications than before. This is the topic of Part 2 of this review as well as discussion of studies pertinent to the mechanisms of action of thalidomide.
Talídómíð var upphaflega svefnlyf, róandi lyf og kvíðastillandi lyf, sem byrjað var að nota árið 1955. Það þótti hafa lítil eiturhrif og blíða verkun. Talídómíð var í raun illa rannsakað lyf bæði í dýratilraunum og til lækninga, en var engu að síður auglýst af mikilli áfergju, meðal annars handa þunguðum konum. Talídómíð náði þess vegna ótrúlegri útbreiðslu. Árið 1961 varð ljóst að talídómíð gat í venjulegum skömmtum valdið alvarlegum skemmdum í úttaugakerfi og einnig hörmulegum fósturskemmdum. Talídómíð var því víðast tekið af markaði og notkun þess bönnuð. Fáum árum síðar vaknaði engu að síður áhugi á að nota talídómíð á aðrar ábendingar en áður. Um það er fjallað í síðari hluta þessa yfirlits svo og um rannsóknir er lúta að verkunum og verkunarháttum talídómíðs.
Description
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links
http://www.laeknabladid.is
Collections
Icelandic Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Mechanisms of action and potential therapeutic uses of thalidomide.
  • Authors: Mujagić H, Chabner BA, Mujagić Z
  • Issue date: 2002 Jun
  • [Novel potential uses of thalidomide in the management of pain? A review of the literature].
  • Authors: Peuckmann V, Strumpf M, Zenz M, Bruera E
  • Issue date: 2003 Jun
  • The legal standards for the radioactive or non radioactive drugs research and approval in the European Community and in Germany after the thalidomide catastrophe.
  • Authors: Barsch M, Otte A
  • Issue date: 2010 Jan-Apr
  • Thalidomide: an old sedative-hypnotic with anticancer activity?
  • Authors: Gasparini G, Morabito A, Magnani E, Gattuso D, Capaccetti B, Alberti AM
  • Issue date: 2001 Sep
  • Thalidomide: 40 years on.
  • Authors: Diggle GE
  • Issue date: 2001 Nov

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.