Reaction time and sustained attention in schizophrenia and its genetic predisposition
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationSchizophr. Res. 2007, 95(1-3):76-85
AbstractSustained attention is affected by schizophrenia. The simplest form of Continuous Performance Test (CPT-X) is a purer test of vigilance than more demanding variants but widely thought too insensitive to detect abnormalities in those with genetic predisposition to schizophrenia. We used a 7-minute CPT to compare 61 patients diagnosed with schizophrenia, 45 of their never-psychotic relatives, and 47 control subjects. We found a significant impairment in stimulus discrimination in both patients (p=0.001) and their relatives (p=0.006). There was no difference in stimulus discrimination between relatives of patients with impaired and unimpaired stimulus discrimination. Relatives of patients with unimpaired stimulus discrimination were still inferior to controls (p=0.02). Reactions slowed in all groups equally as the test progressed. Patients showed increased mean reaction time (p<0.0001) and interquartile range (p=0.003). Relatives showed slower reaction times (p=0.01) but normal interquartile range. Groups did not differ in respect of individuals' fastest reaction times. We conclude that genetic predisposition to schizophrenia reduces performance even during a task placing minimal cognitive load on working memory and perceptual processing, suggesting impaired vigilance. Increased reaction time in the disease and its predisposition appear to be due to changes in response distribution rather than by a limitation of maximum speed. Our results raise the possibility of separating the cognitive components of vigilance, working memory and perceptual processing tapped by more demanding variants of the CPT, and draw attention to the need for consideration of dynamic neurocognitive processes in schizophrenia.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Deficits in visual sustained attention differentiate genetic liability and disease expression for schizophrenia from Bipolar Disorder.
- Authors: Kumar CT, Christodoulou T, Vyas NS, Kyriakopoulos M, Corrigall R, Reichenberg A, Frangou S
- Issue date: 2010 Dec
- Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients.
- Authors: Chen WJ, Liu SK, Chang CJ, Lien YJ, Chang YH, Hwu HG
- Issue date: 1998 Sep
- Continuous performance test and schizophrenia: a test of stimulus-response compatibility, working memory, response readiness, or none of the above?
- Authors: Elvevåg B, Weinberger DR, Suter JC, Goldberg TE
- Issue date: 2000 May
- Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.
- Authors: Purdon SE, Valiakalayil A, Hanstock CC, Seres P, Tibbo P
- Issue date: 2008 Feb
- Cognitive performance and basic symptoms in first-degree relatives of schizophrenic patients.
- Authors: Bove EA
- Issue date: 2008 Jul-Aug