Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
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Authors
Gudmundsson, JuliusSulem, Patrick
Steinthorsdottir, Valgerdur
Bergthorsson, Jon T
Thorleifsson, Gudmar
Manolescu, Andrei
Rafnar, Thorunn
Gudbjartsson, Daniel
Agnarsson, Bjarni A
Baker, Adam
Sigurdsson, Asgeir
Benediktsdottir, Kristrun R
Jakobsdottir, Margret
Blondal, Thorarinn
Stacey, Simon N
Helgason, Agnar
Gunnarsdottir, Steinunn
Olafsdottir, Adalheidur
Kristinsson, Kari T
Birgisdottir, Birgitta
Ghosh, Shyamali
Thorlacius, Steinunn
Magnusdottir, Dana
Stefansdottir, Gerdur
Kristjansson, Kristleifur
Bagger, Yu
Wilensky, Robert L
Reilly, Muredach P
Morris, Andrew D
Kimber, Charlotte H
Adeyemo, Adebowale
Chen, Yuanxiu
Zhou, Jie
So, Wing-Yee
Tong, Peter C Y
Ng, Maggie C Y
Hansen, Torben
Andersen, Gitte
Borch-Johnsen, Knut
Jorgensen, Torben
Tres, Alejandro
Fuertes, Fernando
Ruiz-Echarri, Manuel
Asin, Laura
Saez, Berta
van Boven, Erica
Klaver, Siem
Swinkels, Dorine W
Aben, Katja K
Graif, Theresa
Cashy, John
Suarez, Brian K
van Vierssen Trip, Onco
Frigge, Michael L
Ober, Carole
Hofker, Marten H
Wijmenga, Cisca
Christiansen, Claus
Rader, Daniel J
Palmer, Colin N A
Rotimi, Charles
Chan, Juliana C N
Pedersen, Oluf
Sigurdsson, Gunnar
Benediktsson, Rafn
Jonsson, Eirikur
Einarsson, Gudmundur V
Mayordomo, Jose I
Catalona, William J
Kiemeney, Lambertus A
Barkardottir, Rosa B
Gulcher, Jeffrey R
Thorsteinsdottir, Unnur
Kong, Augustine
Stefansson, Kari
Issue Date
2007-08-01
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Nat. Genet. 2007, 39(8):977-83Abstract
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1038/ng2062ae974a485f413a2113503eed53cd6c53
10.1038/ng2062
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