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dc.contributor.authorGudmundsson, Julius
dc.contributor.authorSulem, Patrick
dc.contributor.authorSteinthorsdottir, Valgerdur
dc.contributor.authorBergthorsson, Jon T
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorManolescu, Andrei
dc.contributor.authorRafnar, Thorunn
dc.contributor.authorGudbjartsson, Daniel
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorBaker, Adam
dc.contributor.authorSigurdsson, Asgeir
dc.contributor.authorBenediktsdottir, Kristrun R
dc.contributor.authorJakobsdottir, Margret
dc.contributor.authorBlondal, Thorarinn
dc.contributor.authorStacey, Simon N
dc.contributor.authorHelgason, Agnar
dc.contributor.authorGunnarsdottir, Steinunn
dc.contributor.authorOlafsdottir, Adalheidur
dc.contributor.authorKristinsson, Kari T
dc.contributor.authorBirgisdottir, Birgitta
dc.contributor.authorGhosh, Shyamali
dc.contributor.authorThorlacius, Steinunn
dc.contributor.authorMagnusdottir, Dana
dc.contributor.authorStefansdottir, Gerdur
dc.contributor.authorKristjansson, Kristleifur
dc.contributor.authorBagger, Yu
dc.contributor.authorWilensky, Robert L
dc.contributor.authorReilly, Muredach P
dc.contributor.authorMorris, Andrew D
dc.contributor.authorKimber, Charlotte H
dc.contributor.authorAdeyemo, Adebowale
dc.contributor.authorChen, Yuanxiu
dc.contributor.authorZhou, Jie
dc.contributor.authorSo, Wing-Yee
dc.contributor.authorTong, Peter C Y
dc.contributor.authorNg, Maggie C Y
dc.contributor.authorHansen, Torben
dc.contributor.authorAndersen, Gitte
dc.contributor.authorBorch-Johnsen, Knut
dc.contributor.authorJorgensen, Torben
dc.contributor.authorTres, Alejandro
dc.contributor.authorFuertes, Fernando
dc.contributor.authorRuiz-Echarri, Manuel
dc.contributor.authorAsin, Laura
dc.contributor.authorSaez, Berta
dc.contributor.authorvan Boven, Erica
dc.contributor.authorKlaver, Siem
dc.contributor.authorSwinkels, Dorine W
dc.contributor.authorAben, Katja K
dc.contributor.authorGraif, Theresa
dc.contributor.authorCashy, John
dc.contributor.authorSuarez, Brian K
dc.contributor.authorvan Vierssen Trip, Onco
dc.contributor.authorFrigge, Michael L
dc.contributor.authorOber, Carole
dc.contributor.authorHofker, Marten H
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorChristiansen, Claus
dc.contributor.authorRader, Daniel J
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorRotimi, Charles
dc.contributor.authorChan, Juliana C N
dc.contributor.authorPedersen, Oluf
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorBenediktsson, Rafn
dc.contributor.authorJonsson, Eirikur
dc.contributor.authorEinarsson, Gudmundur V
dc.contributor.authorMayordomo, Jose I
dc.contributor.authorCatalona, William J
dc.contributor.authorKiemeney, Lambertus A
dc.contributor.authorBarkardottir, Rosa B
dc.contributor.authorGulcher, Jeffrey R
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorKong, Augustine
dc.contributor.authorStefansson, Kari
dc.date.accessioned2007-11-05T08:37:30Z
dc.date.available2007-11-05T08:37:30Z
dc.date.issued2007-08-01
dc.date.submitted2007-11-05
dc.identifier.citationNat. Genet. 2007, 39(8):977-83en
dc.identifier.issn1061-4036
dc.identifier.pmid17603485
dc.identifier.doi10.1038/ng2062
dc.identifier.urihttp://hdl.handle.net/2336/14444
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng2062en
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromosomes, Human, Pair 17en
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHaplotypesen
dc.subject.meshHepatocyte Nuclear Factor 1-betaen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshProstatic Neoplasmsen
dc.titleTwo variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesen
dc.typeArticleen
dc.identifier.journalNature geneticsen
dc.format.digYES
html.description.abstractWe performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.


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