Detection of small implanted tumors growing during repeated magnetic resonance imaging of the rabbit liver: application of an interpretation model.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationActa Radiol 2004, 45(5):547-55
AbstractPURPOSE: To apply experimentally and further develop a new image interpretation model based on repeated imaging and aimed at improving assessments of technical efficacy and diagnostic accuracy in the detection of small lesions. MATERIAL AND METHODS: VX2 carcinoma was implanted in the liver of 14 rabbits as two 1.1-1.7 mm3 cores. Magnetic resonance imaging was performed before and 4 days after implantation and then every second day up to the 14th to 20th day. One T2-weighted sequence (TSE T2) and three T1-weighted sequences (SE T1, GE T1, and TFL T1) were used. Interpretation was performed stepwise: three readers independently interpreted image sequences chronologically (step 1). Tumors were included at the last examination (step 2). By concurrent interpretation of repeated examinations, the earliest day at which tumors became visible and tumor size were recorded (step 3). Records were corrected (step 4) and autopsy was performed (step 5). Two procedures for use in calculating repeated detection rates of tumors with different magnetic resonance imaging sequences are presented and discussed. RESULTS: Of 40 macroscopic tumors, 34 were included. They were mainly small (size range SE T1: 1-3mm, TSE T2: 1.5-5 mm) when they became visible as determined at step 3, which was consistently earlier than observed at step 1. TSE T2, SE T1, and GE T1 did not differ significantly regarding earliest day of detection (step 3), while TFL T1 revealed the tumors later. The initial repeated detection rates were higher with TSE T2 than with the other sequences. Frequency of false positives varied over time, indicating fluctuating criteria for reporting tumors. CONCLUSION: A theoretical image interpretation model previously described proved to be applicable for detection of experimental liver tumors. The model was improved by introducing calculations of repeated detection rates for initial image interpretation using an imaging reference standard.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Validation of diagnostic imaging based on repeat examinations. An image interpretation model.
- Authors: Isberg B, Thorstensen O, Jorulf H
- Issue date: 2004 Aug
- Phased array breath-hold versus non-breath-hold MR imaging of focal liver lesions: a prospective comparative study.
- Authors: Yamashita Y, Yamamoto H, Namimoto T, Abe Y, Takahashi M
- Issue date: 1997 Mar-Apr
- [Dynamic evaluation of rabbit VX2 hepatic carcinoma with CT and MRI].
- Authors: Jia HS, Quan XY, Zeng S, Wen ZB
- Issue date: 2002 Feb
- Preoperative detection of malignant liver tumors: Comparison of 3D-T2-weighted sequences with T2-weighted turbo spin-echo and single shot T2 at 1.5 T.
- Authors: Barat M, Soyer P, Dautry R, Pocard M, Lo-Dico R, Najah H, Eveno C, Cassinotto C, Dohan A
- Issue date: 2018 Mar
- Characteristics of liver on magnetic resonance diffusion-weighted imaging: dynamic and image pathological investigation in rabbit liver VX-2 tumor model.
- Authors: Yuan YH, Xiao EH, Liu JB, He Z, Jin K, Ma C, Xiang J, Xiao JH, Chen WJ
- Issue date: 2008 Jul 7