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dc.contributor.authorSvendsen, Kristina B
dc.contributor.authorAndersen, Steen
dc.contributor.authorArnason, Sigurdur
dc.contributor.authorArnér, Staffan
dc.contributor.authorBreivik, Harald
dc.contributor.authorHeiskanen, Tarja
dc.contributor.authorKalso, Eija
dc.contributor.authorKongsgaard, Ulf E
dc.contributor.authorSjogren, Per
dc.contributor.authorStrang, Peter
dc.contributor.authorBach, Flemming W
dc.contributor.authorJensen, Troels S
dc.date.accessioned2007-11-12T15:02:57Z
dc.date.available2007-11-12T15:02:57Z
dc.date.issued2005-04-01
dc.date.submitted2007-11-12
dc.identifier.citationEur J Pain 2005, 9(2):195-206en
dc.identifier.issn1090-3801
dc.identifier.pmid15737812
dc.identifier.doi10.1016/j.ejpain.2004.06.001
dc.identifier.urihttp://hdl.handle.net/2336/14516
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBreakthrough pain or transient worsening of pain in patients with an ongoing steady pain is a well known feature in cancer pain patients, but it is also seen in non-malignant pain conditions with involvement of nerves, muscles, bones or viscera. Continuous and intermittent pain seems to be a general feature of these different pain conditions, and this raises the possibility of one or several common mechanisms underlying breakthrough pain in malignant and non-malignant disorders. Although the mechanisms of spontaneous ongoing pain and intermittent flares of pain (BTP) may be difficult to separate, we suggest that peripheral and/or central sensitization (hyperexcitability) may play a major role in many causes of BTP. Mechanical stimuli (e.g. micro-fractures) changes in chemical environments and release of tumour growth factors may initiate sensitization both peripherally and centrally. It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain.
dc.language.isoenen
dc.publisherSaundersen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WF3-4CP68R7-1/2/05224b60895cb4aa489a22cb8d79c708en
dc.subject.meshPainen
dc.subject.meshPain Measurementen
dc.subject.meshPrevalenceen
dc.subject.meshSomatosensory Disordersen
dc.titleBreakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanismsen
dc.typeArticleen
dc.identifier.eissn1532-2149
dc.identifier.journalEuropean journal of pain (London, England)en
dc.format.digYES
html.description.abstractBreakthrough pain or transient worsening of pain in patients with an ongoing steady pain is a well known feature in cancer pain patients, but it is also seen in non-malignant pain conditions with involvement of nerves, muscles, bones or viscera. Continuous and intermittent pain seems to be a general feature of these different pain conditions, and this raises the possibility of one or several common mechanisms underlying breakthrough pain in malignant and non-malignant disorders. Although the mechanisms of spontaneous ongoing pain and intermittent flares of pain (BTP) may be difficult to separate, we suggest that peripheral and/or central sensitization (hyperexcitability) may play a major role in many causes of BTP. Mechanical stimuli (e.g. micro-fractures) changes in chemical environments and release of tumour growth factors may initiate sensitization both peripherally and centrally. It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain.


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