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dc.contributor.authorLudvigsson, Petur
dc.contributor.authorHesdorffer, Dale
dc.contributor.authorOlafsson, Elias
dc.contributor.authorKjartansson, Olafur
dc.contributor.authorHauser, W Allen
dc.date.accessioned2007-11-12T15:41:14Z
dc.date.available2007-11-12T15:41:14Z
dc.date.issued2006-01-01
dc.date.submitted2007-11-12
dc.identifier.citationAnn. Neurol. 2006, 59(1):210-3en
dc.identifier.issn0364-5134
dc.identifier.pmid16374824
dc.identifier.doi10.1002/ana.20745
dc.identifier.otherPED12
dc.identifier.urihttp://hdl.handle.net/2336/14517
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: Migraine is associated with epilepsy, but the time order and nature of the relationship are unclear. We conducted a population based case control study to clarify the time order to determine whether migraine is a risk factor for epilepsy. METHODS: Migraine symptoms were evaluated in a population-based case-control study of all incident epilepsy in Icelandic children and in matched controls (next two same sex births in the country). RESULTS: Migraine was associated with a fourfold increased risk for developing epilepsy, an association explained by migraine with aura (odds ratio, 8.1; 95% confidence interval, 2.7-24.3). Migraine without aura did not increase risk for epilepsy. INTERPRETATION: Children with migraine with aura have a substantial increased risk to develop subsequent epilepsy. This finding is consistent with the hypothesis that migraine with aura and migraine without aura may be different disorders.
dc.language.isoenen
dc.publisherWiley-Lissen
dc.relation.urlhttp://dx.doi.org/10.1002/ana.20745en
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshEpilepsyen
dc.subject.meshIcelanden
dc.subject.meshMigraine with Auraen
dc.subject.meshRisk Factorsen
dc.subject.meshCase-Control Studiesen
dc.titleMigraine with aura is a risk factor for unprovoked seizures in childrenen
dc.typeArticleen
dc.identifier.journalAnnals of neurologyen
dc.format.digYES
html.description.abstractOBJECTIVE: Migraine is associated with epilepsy, but the time order and nature of the relationship are unclear. We conducted a population based case control study to clarify the time order to determine whether migraine is a risk factor for epilepsy. METHODS: Migraine symptoms were evaluated in a population-based case-control study of all incident epilepsy in Icelandic children and in matched controls (next two same sex births in the country). RESULTS: Migraine was associated with a fourfold increased risk for developing epilepsy, an association explained by migraine with aura (odds ratio, 8.1; 95% confidence interval, 2.7-24.3). Migraine without aura did not increase risk for epilepsy. INTERPRETATION: Children with migraine with aura have a substantial increased risk to develop subsequent epilepsy. This finding is consistent with the hypothesis that migraine with aura and migraine without aura may be different disorders.


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