Skin toxicity as a risk factor for major infections in breast cancer patients treated with docetaxel
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Nittby, Lena Tennvall
Madsen, Ebbe Lindegaard
MetadataShow full item record
CitationActa Oncol 2004, 43(2):190-5
ÚtdrátturDocetaxel-related skin toxicity, oral and gastrointestinal mucosal toxicity, and changes in blood cell counts were investigated as predictive factors for major infections in 143 women treated with 3-weekly docetaxel (100 mg/m2) as second-line therapy for metastatic breast cancer in a randomized trial. Each patient with a major infection (n = 37) was compared with two controls. Skin toxicity (odds ratio 2.97, 95% CI 1.37-6.47), oral mucositis (1.98, CI 1.30-3.04), and the leukocyte nadir (0.12, CI 0.02-0.51) were significantly associated with a major infection in a univariate logistic regression analysis. In a multivariate analysis, skin toxicity was the only independent factor predictive for grade 3 to 4 infection (2.75, CI 1.00-7.58). A major infection was diagnosed in 62% (8 out of 13) of the docetaxel cycles in severely (grade 4) leukopenic patients who had grade 2 to 4 skin toxicity. Major infections are common in leukopenic patients who develop docetaxel-associated skin toxicity, and leukopenic patients presenting with docetaxel-induced skin toxicity may be candidates for prophylactic anti-infection measures such as prophylactic therapy with hematopoietic growth factors.
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- Corticosteroids significantly delay the onset of docetaxel-induced fluid retention: final results of a randomized study of the European Organization for Research and Treatment of Cancer Investigational Drug Branch for Breast Cancer.
- Authors: Piccart MJ, Klijn J, Paridaens R, Nooij M, Mauriac L, Coleman R, Bontenbal M, Awada A, Selleslags J, Van Vreckem A, Van Glabbeke M
- Issue date: 1997 Sep
- Activity and toxicity of docetaxel (Taxotere) in women with previously treated metastatic breast cancer.
- Authors: Shapiro JD, Millward MJ, Rischin D, Davison JD, Michael M, Francis PA, Ganju V, Toner GC
- Issue date: 1997 Feb
- Multicenter randomized trial comparing sequential with concomitant administration of doxorubicin and docetaxel as first-line treatment of metastatic breast cancer: a Spanish Breast Cancer Research Group (GEICAM-9903) phase III study.
- Authors: Alba E, Martín M, Ramos M, Adrover E, Balil A, Jara C, Barnadas A, Fernández-Aramburo A, Sánchez-Rovira P, Amenedo M, Casado A, Spanish Breast Cancer Research Group.
- Issue date: 2004 Jul 1
- Phase I study of docetaxel administered by bi-weekly infusion to patients with metastatic breast cancer.
- Authors: Shin E, Ishitobi M, Hiraoia M, Kazumasa F, Hideyuki M, Nishisho I, Toshiro S, Yasunori H, Tosimasa T
- Issue date: 2000 Nov-Dec
- A phase II study of weekly docetaxel in patients with anthracycline pretreated metastatic breast cancer.
- Authors: Ford HE, Yap YS, Miles DW, Makris A, Hall M, Miller L, Harries M, Smith IE, Johnston SR
- Issue date: 2006 Dec