The effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis
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CitationThe effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis. 2003, 148 (5):996-1000 Br. J. Dermatol.
AbstractBACKGROUND: T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. OBJECTIVES: To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. METHODS: Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. RESULTS: A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. CONCLUSIONS: UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.
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- Interleukin-12 alone can not enhance the expression of the cutaneous lymphocyte associated antigen (CLA) by superantigen-stimulated T lymphocytes.
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- CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry.
- Authors: Ferenczi K, Burack L, Pope M, Krueger JG, Austin LM
- Issue date: 2000 Feb
- Peripheral blood lymphocytes from psoriatic patients are hyporesponsive to beta-streptococcal superantigens.
- Authors: Horiuchi N, Aiba S, Ozawa H, Sugawara S, Rikiishi H, Kumagai K, Tagami H
- Issue date: 1998 Feb
- Enhanced proliferation and activation of peripheral blood mononuclear cells in patients with psoriasis vulgaris mediated by streptococcal antigen with bacterial DNA.
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