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dc.contributor.authorSigmundsdottir, H
dc.contributor.authorGudjonsson, J E
dc.contributor.authorValdimarsson, H
dc.date.accessioned2007-12-20T11:07:59Z
dc.date.available2007-12-20T11:07:59Z
dc.date.issued2003-05-01
dc.date.submitted2007-12-20
dc.identifier.citationThe effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis. 2003, 148 (5):996-1000 Br. J. Dermatol.en
dc.identifier.issn0007-0963
dc.identifier.pmid12786832
dc.identifier.doi10.1046/j.1365-2133.2003.05318.x
dc.identifier.urihttp://hdl.handle.net/2336/15442
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. OBJECTIVES: To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. METHODS: Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. RESULTS: A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. CONCLUSIONS: UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2133.2003.05318.xen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAntigens, Bacterialen
dc.subject.meshAntigens, CDen
dc.subject.meshAntigens, CD3en
dc.subject.meshAntigens, Differentiation, T-Lymphocyteen
dc.subject.meshAntigens, Neoplasmen
dc.subject.meshBiological Markersen
dc.subject.meshCells, Cultureden
dc.subject.meshFlow Cytometryen
dc.subject.meshFluorescent Antibody Techniqueen
dc.subject.meshHumansen
dc.subject.meshIntegrin alpha Chainsen
dc.subject.meshLymphocyte Activationen
dc.subject.meshMembrane Glycoproteinsen
dc.subject.meshPUVA Therapyen
dc.subject.meshPsoriasisen
dc.subject.meshReceptors, Interleukin-2en
dc.subject.meshStreptococcus pyogenesen
dc.subject.meshSuperantigensen
dc.subject.meshT-Lymphocytesen
dc.titleThe effects of ultraviolet B treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasisen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland.en
dc.identifier.journalBritish journal of dermatologyen
html.description.abstractBACKGROUND: T lymphocytes are believed to play a role in the pathogenesis of psoriasis; > 80% of T lymphocytes that infiltrate psoriatic lesions express the surface glycoprotein cutaneous lymphocyte-associated antigen (CLA), compared with < 20% in the blood. Exposure to ultraviolet (UV) B is an effective treatment for psoriasis. OBJECTIVES: To compare the effects of UVB treatment of psoriasis on the expression of CLA and several other surface markers expressed by circulating T lymphocytes. METHODS: Peripheral blood mononuclear cells from psoriatic patients were stained for adhesion molecules and stimulated with streptococcal antigens before and once weekly during 3 weeks of UVB treatment. RESULTS: A marked and progressive decrease was observed during the treatment in expression of the CLA and the very late antigen-4alpha by T cells; this decrease correlated closely with clinical improvement (Psoriasis Area and Severity Index). T-cell expression of intercellular adhesion molecule-1 was not significantly affected during the treatment and no change was observed in the activation markers CD25 and CD69 or lymphocyte proliferation after stimulation with streptococcal antigens or superantigens. CONCLUSIONS: UVB treatment is associated with a marked reduction in the expression of skin-homing molecules by circulating T cells. This may be relevant to the therapeutic effect of UVB in psoriasis.


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