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An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival

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Authors
Arason, Gudmundur Johann
Bodvarsson, Sigurdur
Sigurdarson, Sigurdur Thor
Sigurdsson, Gardar
Thorgeirsson, Gudmundur
Gudmundsson, Sveinn
Kramer, Judit
Füst, Georg
Issue Date
2003-12-01

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Citation
Ann N Y Acad Sci. 2003, 1010:496-9
Abstract
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
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http://www.blackwell-synergy.com/doi/abs/10.1196/annals.1299.091
ae974a485f413a2113503eed53cd6c53
10.1196/annals.1299.091
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English Journal Articles (Peer Reviewed)

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