An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival

Cast your vote
 
Your vote was cast
Thank you for your feedback
Authors
Arason, Gudmundur Johann
Bodvarsson, Sigurdur
Sigurdarson, Sigurdur Thor
Sigurdsson, Gardar
Thorgeirsson, Gudmundur
Gudmundsson, Sveinn
Kramer, Judit
Füst, Georg
Issue Date
2003-12-01

Metadata
Show full item record
Citation
Ann N Y Acad Sci. 2003, 1010:496-9
Abstract
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://www.blackwell-synergy.com/doi/abs/10.1196/annals.1299.091
Collections