An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival
| dc.contributor.author | Arason, Gudmundur Johann | |
| dc.contributor.author | Bodvarsson, Sigurdur | |
| dc.contributor.author | Sigurdarson, Sigurdur Thor | |
| dc.contributor.author | Sigurdsson, Gardar | |
| dc.contributor.author | Thorgeirsson, Gudmundur | |
| dc.contributor.author | Gudmundsson, Sveinn | |
| dc.contributor.author | Kramer, Judit | |
| dc.contributor.author | Füst, Georg | |
| dc.date.accessioned | 2007-12-20T13:31:21Z | |
| dc.date.available | 2007-12-20T13:31:21Z | |
| dc.date.issued | 2003-12-01 | |
| dc.date.submitted | 2007-12-20 | |
| dc.identifier.citation | Ann N Y Acad Sci. 2003, 1010:496-9 | en |
| dc.identifier.issn | 0077-8923 | |
| dc.identifier.pmid | 15033778 | |
| dc.identifier.doi | 10.1196/annals.1299.091 | |
| dc.identifier.uri | http://hdl.handle.net/2336/15445 | |
| dc.description | To access publisher full text version of this article. Please click on the hyperlink in Additional Links field | en |
| dc.description.abstract | We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival. | |
| dc.language.iso | en | en |
| dc.publisher | New York Academy of Sciences | en |
| dc.relation.url | http://www.blackwell-synergy.com/doi/abs/10.1196/annals.1299.091 | en |
| dc.subject.mesh | Adolescent | en |
| dc.subject.mesh | Adult | en |
| dc.subject.mesh | Aged | en |
| dc.subject.mesh | Aged, 80 and over | en |
| dc.subject.mesh | Aging | en |
| dc.subject.mesh | Complement C3 | en |
| dc.subject.mesh | Complement C4b | en |
| dc.subject.mesh | Complement System Proteins | en |
| dc.subject.mesh | Gene Frequency | en |
| dc.subject.mesh | HLA-B Antigens | en |
| dc.subject.mesh | Health Status | en |
| dc.subject.mesh | Humans | en |
| dc.subject.mesh | Iceland | en |
| dc.subject.mesh | Middle Aged | en |
| dc.subject.mesh | Survivors | en |
| dc.subject.mesh | Variation (Genetics) | en |
| dc.title | An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival | en |
| dc.type | Article | en |
| dc.identifier.journal | Annals of the New York Academy of Sciences | en |
| html.description.abstract | We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival. |