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dc.contributor.authorArason, Gudmundur Johann
dc.contributor.authorBodvarsson, Sigurdur
dc.contributor.authorSigurdarson, Sigurdur Thor
dc.contributor.authorSigurdsson, Gardar
dc.contributor.authorThorgeirsson, Gudmundur
dc.contributor.authorGudmundsson, Sveinn
dc.contributor.authorKramer, Judit
dc.contributor.authorFüst, Georg
dc.date.accessioned2007-12-20T13:31:21Z
dc.date.available2007-12-20T13:31:21Z
dc.date.issued2003-12-01
dc.date.submitted2007-12-20
dc.identifier.citationAnn N Y Acad Sci. 2003, 1010:496-9en
dc.identifier.issn0077-8923
dc.identifier.pmid15033778
dc.identifier.doi10.1196/annals.1299.091
dc.identifier.urihttp://hdl.handle.net/2336/15445
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
dc.language.isoenen
dc.publisherNew York Academy of Sciencesen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1196/annals.1299.091en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAgingen
dc.subject.meshComplement C3en
dc.subject.meshComplement C4ben
dc.subject.meshComplement System Proteinsen
dc.subject.meshGene Frequencyen
dc.subject.meshHLA-B Antigensen
dc.subject.meshHealth Statusen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMiddle Ageden
dc.subject.meshSurvivorsen
dc.subject.meshVariation (Genetics)en
dc.titleAn age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survivalen
dc.typeArticleen
dc.identifier.journalAnnals of the New York Academy of Sciencesen
html.description.abstractWe studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.


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