Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development
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Authors
Sigurjonsson, Olafur EysteinnGudmundsson, Kristbjorn Orri
Haraldsdottir, Vilhelmina
Rafnar, Thorunn
Agnarsson, Bjarni A
Gudmundsson, Sveinn
Issue Date
2004-04-01
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Stem Cells Dev. 2004, 13(2):183-91Abstract
The growth factors thrombopoietin (TPO) and Flt3/Flk-2-ligand (FL), either independently or in combination, modulate megakaryocyte development. Our results show that bone marrow CD34+ cells cultured with TPO and FL differentiate at a slower rate into CD41+ cells and are delayed in apoptosis at the later stages of the cultures compared to cells cultured with TPO alone. Our data also show that FL in synergy with TPO may inhibit apoptosis in megakaryocyte development by up-regulating bcl-2 and inducing conformational changes of p53, in MK progenitors. FL in combination with TPO slows down maturation and consequently delays apoptosis of MK progenitor cells.Description
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http://www.liebertonline.com/doi/abs/10.1089/154732804323046783ae974a485f413a2113503eed53cd6c53
10.1089/154732804323046783
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