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Post-induction residual disease in translocation t(12;21)-positive childhood ALL

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Authors
Seyfarth, Jeanette
Madsen, Hans O
Nyvold, Charlotte
Ryder, Lars P
Clausen, Niels
Jonmundsson, Gudmundur K
Wesenberg, Finn
Schmiegelow, Kjeld
Issue Date
2003-02-01

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Citation
Med. Pediatr. Oncol. 2003, 40(2):82-7
Abstract
BACKGROUND: t(12;21)(p1 3;q22), the most frequent chromosomal translocation found in childhood acute lymphoblastic leukemia (ALL), occurs in approximately 25% of B-lineage ALL cases and has been claimed to carry a good prognosis. PROCEDURE: As part of the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL-MRD 95 study, which includes children from Iceland, Norway, and Denmark diagnose d with ALL, patients were screened for the presence of t(12; 21) by reverse transcriptase-polymerase chain reaction (RT-PCR) at diagnosis, and their residual disease was quantified after 4 weeks of induction therapy (prednisolone, vincristine, doxorubicin, i.t. methotrexate) by a competitive, clone-specific, semi-nested PCR analysis. RESULTS: Among 96 children diagnosed with ALL, and quantified for post induction residual disease, 32 were t(12;21)-positive. The median residual disease was similar for B-precursor ALL patients with and without t(12;21) (0.009 vs. 0.03%, P = 0.12). CONCLUSIONS: Al though patients with t(12;21)-positive ALL have been claimed to have a good outcome, these data indicate that this does not reflect a high sensitivity to prednisolone, vincristine, and doxorubicin given during induction therapy.
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http://dx.doi.org/10.1002/mpo.10217
ae974a485f413a2113503eed53cd6c53
10.1002/mpo.10217
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