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dc.contributor.authorAccordini, S
dc.contributor.authorCorsico, A
dc.contributor.authorCerveri, I
dc.contributor.authorGislason, D
dc.contributor.authorGulsvik, A
dc.contributor.authorJanson, C
dc.contributor.authorJarvis, D
dc.contributor.authorMarcon, A
dc.contributor.authorPin, I
dc.contributor.authorVermeire, P
dc.contributor.authorAlmar, E
dc.contributor.authorBugiani, M
dc.contributor.authorCazzoletti, L
dc.contributor.authorDuran-Tauleria, E
dc.contributor.authorJõgi, R
dc.contributor.authorMarinoni, A
dc.contributor.authorMartínez-Moratalla, J
dc.contributor.authorLeynaert, B
dc.contributor.authorde Marco, R
dc.date.accessioned2008-01-11T10:30:25Z
dc.date.available2008-01-11T10:30:25Z
dc.date.issued2008-01-01
dc.date.submitted2008-01-11
dc.identifier.citationAllergy. 2008, 63(1):116-24en
dc.identifier.issn0105-4538
dc.identifier.pmid18053021
dc.identifier.doi10.1111/j.1398-9995.2007.01523.x
dc.identifier.urihttp://hdl.handle.net/2336/15958
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Few data are available on the asthma burden in the general population. We evaluated the level and the factors associated with the asthma burden in Europe. METHODS: In 1999-2002, 1152 adult asthmatics were identified in the European Community Respiratory Health Survey (ECRHS)-II and the socio-economic burden (reduced activity days and hospital services utilization in the past 12 months) was assessed. RESULTS: The asthmatics with a light burden (only a few reduced activity days) were 13.2% (95% CI: 11.4-15.3%), whereas those with a heavy burden (many reduced activity days and/or hospital services utilization) were 14.0% (95% CI: 12.1-16.1%). The burden was strongly associated with disease severity and a lower quality of life. Obese asthmatics had a significantly increased risk of a light [relative risk ratio (RRR) = 2.17; 95% CI: 1.18-4.00] or a heavy burden (RRR = 2.77; 95% CI: 1.52-5.05) compared with normal/underweight subjects. The asthmatics with frequent respiratory symptoms showed a threefold (RRR = 2.74; 95% CI: 1.63-4.61) and sixfold (RRR = 5.76; 95% CI: 3.25-10.20) increased risk of a light or a heavy burden compared with asymptomatic asthmatics, respectively. Moreover, the lower the forced expiratory volume in 1 s % predicted, the higher the risk of a heavy burden. The coexistence with chronic cough/phlegm only increased the risk of a heavy burden (RRR = 1.88; 95% CI: 1.16-3.06). An interaction was found between gender and IgE sensitization, with nonatopic asthmatic females showing the highest risk of a heavy burden (21.6%; 95% CI: 16.9-27.1%). CONCLUSIONS: The asthma burden is substantial in Europe. A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms, low lung function, chronic cough/phlegm and in nonatopic females.
dc.language.isoenen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.1398-9995.2007.01523.xen
dc.subject.meshPubMed - in processen
dc.titleThe socio-economic burden of asthma is substantial in Europeen
dc.typeArticleen
dc.identifier.eissn1398-9995
dc.identifier.journalAllergyen
html.description.abstractBACKGROUND: Few data are available on the asthma burden in the general population. We evaluated the level and the factors associated with the asthma burden in Europe. METHODS: In 1999-2002, 1152 adult asthmatics were identified in the European Community Respiratory Health Survey (ECRHS)-II and the socio-economic burden (reduced activity days and hospital services utilization in the past 12 months) was assessed. RESULTS: The asthmatics with a light burden (only a few reduced activity days) were 13.2% (95% CI: 11.4-15.3%), whereas those with a heavy burden (many reduced activity days and/or hospital services utilization) were 14.0% (95% CI: 12.1-16.1%). The burden was strongly associated with disease severity and a lower quality of life. Obese asthmatics had a significantly increased risk of a light [relative risk ratio (RRR) = 2.17; 95% CI: 1.18-4.00] or a heavy burden (RRR = 2.77; 95% CI: 1.52-5.05) compared with normal/underweight subjects. The asthmatics with frequent respiratory symptoms showed a threefold (RRR = 2.74; 95% CI: 1.63-4.61) and sixfold (RRR = 5.76; 95% CI: 3.25-10.20) increased risk of a light or a heavy burden compared with asymptomatic asthmatics, respectively. Moreover, the lower the forced expiratory volume in 1 s % predicted, the higher the risk of a heavy burden. The coexistence with chronic cough/phlegm only increased the risk of a heavy burden (RRR = 1.88; 95% CI: 1.16-3.06). An interaction was found between gender and IgE sensitization, with nonatopic asthmatic females showing the highest risk of a heavy burden (21.6%; 95% CI: 16.9-27.1%). CONCLUSIONS: The asthma burden is substantial in Europe. A heavy burden is more common in asthmatics with obesity, frequent respiratory symptoms, low lung function, chronic cough/phlegm and in nonatopic females.


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