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Verndandi áhrif lýsisríks fæðis eftir sýkingar eru óháð íkomustað bakteríanna

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Authors
Valtýr Stefánsson Thors
Auður Þórisdóttir
Helga Erlendsdóttir
Ingibjörg Harðardóttir
Ingólfur Einarsson
Jón Reynir Sigurðsson
Sigurður Guðmundsson
Eggert Gunnarsson
Ásgeir Haraldsson
Issue Date
2002-02-01

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Beneficial effect of dietary fish-oil is independent of the infection site
Citation
Læknablaðið 2002, 88(2):117-19
Abstract
Objective: Fish-oil enriched diet has a protective effect on experimental animals infected intramuscularly with Klebsiella pneumoniae. It also has beneficial effect in several other diseases, including autoimmune disorders. The pathophysiological effects of dietary fish-oil have still not been revealed although it is expected to influence the immune response. We have previously shown that dietary fish-oil has beneficial effect in mice infected intramuscularly with Klebsiella pneumoniae. If the beneficial effect of dietary fish-oil is due to influence on the immune response it should be independent of the infection site. We therefore investigated whether dietary fish-oil has beneficial effect in intrapulmonary infection with Klebsiella pneumoniae as it has on intramuscular infection with the same bacteria. Materials and methods: Sixty NMRI mice were fed diets enriched with fish-oil (30 mice) or corn-oil (30 mice) for six weeks. The mice were then infected in the lungs with Klebsiella pneumoniae and the survival was monitored. The experiment was performed twice. The results were compared to our earlier results with intramuscular infections. Results: The survival of the mice fed the fish-oil enriched diet and infected in the lungs with Klebsiella pneumoniae was significantly better compared to the survival of mice fed the corn-oil enriched diet in both experiments (p=0.0001 and p=0.0013). These results are similar to our earlier findings when the mice were infected intramuscularly. Conclusions: These results indicate that the beneficial effect of dietary fish-oil on infection is independent of the site of infection. These results are in accordance with the hypothesis that dietary fish-oil influences the immune response.
Markmið: Lýsisríkt fæði hefur verndandi áhrif á tilraunadýr sem sýkt eru í vöðva með Klebsiella pneumoniae og hefur einnig áhrif í ýmsum sjúkdómum, þar á meðal sjálfnæmissjúkdómum. Ekki er ljóst á hvern hátt lýsið virkar þó líklegt sé að virknin tengist áhrifum lýsis á ónæmissvar dýranna við sýkingunum og öðru áreiti. Rannsóknarhópurinn hefur áður birt niðurstöður sem sýna verndandi áhrif lýsisneyslu í sýkingum með Klebsiella pneumoniae þegar bakteríunni er sprautað í vöðva. Ef verndandi áhrif lýsis í sýkingum tengjast almennt ónæmissvari líkamans ættu þau að koma fram óháð íkomustað sýkingarinnar. Í tilraunum okkar nú var því kannað hvort lýsið hefði sömu verndandi áhrif á tilraunadýr sem sýkt voru í lungu í stað vöðva eins og það gerði í fyrri tilraunum. Efniviður og aðferðir: Sextíu NMRI mýs voru aldar í sex vikur á fæði bættu með lýsi (30 mýs) eða fæði bættu með kornolíu (30 mýs). Eftir það voru mýsnar sýktar í lungu með Klebsiella pneumoniae og fylgst með lifun. Tilraunin var síðan endurtekin á nákvæmlega sama hátt. Niðurstöðurnar voru bornar saman við fyrri tilraunir hópsins þar sem sýkt var í læri. Niðurstöður: Lifun músa sem fengið höfðu lýsisbætt fæði var marktækt betri í báðum tilraununum samanborið við mýs sem aldar voru á kornolíubættu fæði (p=0,0001 og p=0,0013). Niðurstöðurnar eru sambærilegar fyrri niðurstöðum þegar sýkt var í vöðva. Ályktanir: Niðurstöðurnar benda til að jákvæð áhrif lýsisneyslu komi fram óháð íkomustað bakteríanna. Niðurstöðurnar eru því í samræmi við þá kenningu að lýsisneyslan hafi áhrif á ónæmissvar líkamans fremur en afmarkaða staðbundna þætti.
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http://www.laeknabladid.is/2002/2/fraedigreinar//nr/745/
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Icelandic Journal Articles (Peer Reviewed)

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Related articles

  • [Effect of dietary fish-oil on survival of experimental animals after infection with Streptococcus pneumoniae or Klebsiella pneumoniae.].
  • Authors: Thors VS, Thornórisdóttir A, Erlendsdóttir H, Harðardóttir I, Einarsson I, Guðmundsson S, Gunnarsson E, Haraldsson A
  • Issue date: 2002 Feb
  • The effect of dietary fish oil on survival after infection with Klebsiella pneumoniae or Streptococcus pneumoniae.
  • Authors: Thors VS, Thórisdóttir A, Erlendsdóttir H, Einarsson I, Gudmundsson S, Gunnarsson E, Haraldsson A
  • Issue date: 2004
  • [Dietary fish-oil supplementation increases survival in mice following Klebsiella pneumoniae infection.].
  • Authors: Bjornsson S, Hardardottir I, Gunnarsson E, Haraldsson A
  • Issue date: 1997 May
  • Dietary fish oil supplementation increases survival in mice following Klebsiella pneumoniae infection.
  • Authors: Björnsson S, Hardardóttir I, Gunnarsson E, Haraldsson A
  • Issue date: 1997
  • [The effect of dietary fish oil on bacterial growth in vivo.].
  • Authors: Thornórisdóttir A, Sigurðsson JR, Erlendsdóttir H, Einarsson I, Guðmundsson S, Gunnarson E, Harðardóttir I, Haraldsson A
  • Issue date: 2001 Sep

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