Asthma control in Europe: a real-world evaluation based on an international population-based study
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Cazzoletti, LuciaMarcon, Alessandro
Janson, Christer
Corsico, Angelo
Jarvis, Deborah
Pin, Isabelle
Accordini, Simone
Almar, Enrique
Bugiani, Massimiliano
Carolei, Adriana
Cerveri, Isa
Duran-Tauleria, Enric
Gislason, David
Gulsvik, Amund
Jõgi, Rain
Marinoni, Alessandra
Martínez-Moratalla, Jesús
Vermeire, Paul
de Marco, Roberto
Issue Date
2007-12-01
Metadata
Show full item recordCitation
J. Allergy Clin. Immunol. 2007, 120(6):1360-7Abstract
BACKGROUND: Epidemiologic evidence related to asthma control in patients from the general population is scanty. OBJECTIVES: We sought to assess asthma control in several European centers according to the Global Initiative for Asthma (GINA) guidelines and to investigate its determinants. METHODS: In the European Community Respiratory Health Survey II (1999-2002), 1241 adults with asthma were identified and classified into inhaled corticosteroid (ICS) users and non-ICS users in the last year. Control was assessed in both groups by using the GINA proposal (controlled, partly controlled, and uncontrolled asthma), and it was related to potential determinants. RESULTS: Only 15% (95% CI, 12% to 19%) of subjects who had used ICSs in the last year and 45% (95% CI, 41% to 50%) of non-ICS users had their asthma under control; individuals with uncontrolled asthma accounted for 49% (95% CI, 44% to 53%) and 18% (95% CI, 15% to 21%), respectively. Among ICS users, the prevalence of uncontrolled asthma showed great variability across Europe, ranging from 20% (95% CI, 7% to 41%; Iceland) to 67% (95% CI, 35% to 90%; Italy). Overweight status, chronic cough and phlegm, and sensitization to Cladosporium species were associated with poor control in ICS users. About 65% and 87% of ICS users with uncontrolled and partly controlled asthma, respectively, were on a medication regimen that was less than recommended by the GINA guidelines. CONCLUSION: Six of 7 European asthmatic adults using ICSs in the last year did not achieve good disease control. The large majority of subjects with poorly controlled asthma were using antiasthma drugs in a suboptimal way. A wide variability in asthma control emerged across Europe. CLINICAL IMPLICATIONS: Greater attention should be paid to asthma management and to the implementation of the GINA guidelines.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://www.sciencedirect.com/science/article/B6WH4-4R2GWXR-4/2/74e8e5784a243b2ebcd7ceb26f804cf6ae974a485f413a2113503eed53cd6c53
10.1016/j.jaci.2007.09.019
Scopus Count
Collections
Related articles
- Phenotypic determinants of uncontrolled asthma.
- Authors: Siroux V, Boudier A, Bousquet J, Bresson JL, Cracowski JL, Ferran J, Gormand F, Just J, Le Moual N, Morange S, Nadif R, Oryszczyn MP, Pison C, Scheinmann P, Varraso R, Vervloet D, Pin I, Kauffmann F, Epidemiological Study on the Genetics and Environment of Asthma.
- Issue date: 2009 Oct
- Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national Web-based survey.
- Authors: Peters SP, Jones CA, Haselkorn T, Mink DR, Valacer DJ, Weiss ST
- Issue date: 2007 Jun
- Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys.
- Authors: Rabe KF, Adachi M, Lai CK, Soriano JB, Vermeire PA, Weiss KB, Weiss ST
- Issue date: 2004 Jul
- Are the asthma guideline goals achieved in daily practice? A population-based study on treatment adequacy and the control of asthma.
- Authors: de Marco R, Cazzoletti L, Cerveri I, Corsico A, Bugiani M, Accordini S, Carrozzi L, Dallari R, De Togni A, Marinoni A, Pirina P, Janson C, ISAYA Study Group.
- Issue date: 2005 Nov
- Management of chronic asthma in adults in diverse regions of the world.
- Authors: Lalloo UG, McIvor RA
- Issue date: 2006 May