Gender differences in the association between C-reactive protein, lung function impairment, and COPD.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsOlafsdottir, Inga Sif
MetadataShow full item record
CitationInt J Chron Obstruct Pulmon Dis. 2007, 2 (4):635-42
ÚtdrátturIndividuals with COPD have systemic inflammation that can be assessed by measuring C-reactive protein (CRP). In this paper we evaluated whether CRP is related to COPD, lung function and rate of lung function decline. We included 1237 randomly selected subjects (mean age 42, range 28-56 years) from three centers in the European Community Respiratory Health Survey: Reykjavik, Uppsala and Tartu. CRP was measured at the end of the follow-up (mean 8.3 years) and the values were divided into 4 quartiles. Fifty-three non-asthmatic subjects fulfilled spirometric criteria for COPD (FEV1/FVC < 70%). COPD occurred more often in the 4th CRP quartile (OR (95% CI) 3.21 (1.13-9.08)) after adjustment for age, gender, body weight and smoking. High CRP levels were related to lower FEV1 values in both men (-437 (-596, -279) mL) and women (-144 (-243, -44) mL). The negative association between CRP and FEV1 was significantly larger in men than women (p = 0.04). The decline in FEV1 was larger (16 (5, 27) mL) in men with high CRP levels whereas no significant association between CRP and FEV1 decline was found in women. Higher CRP values are significantly associated with COPD and lower lung function in men and women. In men higher CRP values are related to a larger decline in FEV1.
Lu00FDsingTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Change in C-reactive protein levels and FEV1 decline: a longitudinal population-based study.
- Authors: Shaaban R, Kony S, Driss F, Leynaert B, Soussan D, Pin I, Neukirch F, Zureik M
- Issue date: 2006 Dec
- Decline in FEV1 in relation to incident chronic obstructive pulmonary disease in a cohort with respiratory symptoms.
- Authors: Lindberg A, Larsson LG, Rönmark E, Jonsson AC, Larsson K, Lundbäck B
- Issue date: 2007 Mar
- [C-reactive protein level and the correlation between lung function and CRP levels in patients with chronic obstructive pulmonary diseases].
- Authors: Wu SJ, Chen P, Jiang XN, Liu ZJ
- Issue date: 2005 Aug
- Bronchial airflow limitation, smoking, body mass index, and statin use are strongly associated with the C-reactive protein level in the elderly. The Tromsø Study 2001.
- Authors: Melbye H, Halvorsen DS, Hartz I, Medbø A, Brox J, Eggen AE, Njølstad I
- Issue date: 2007 Dec
- [The investigation of the relationship between Leptin-insulin resistance and pulmonary function in patients with chronic obstructive pulmonary disease with acute exacerbation].
- Authors: Pan HY, Lu XZ, Wang DX, Zeng Y, Zhong HB
- Issue date: 2007 Sep