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dc.contributor.authorOlafsdottir, Inga Sif
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorThjodleifsson, Bjarni
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorGislason, David
dc.contributor.authorJõgi, Rain
dc.contributor.authorJanson, Christer
dc.date.accessioned2008-03-07T11:47:46Z
dc.date.available2008-03-07T11:47:46Z
dc.date.issued2007
dc.date.submitted2008-03-07
dc.identifier.citationInt J Chron Obstruct Pulmon Dis. 2007, 2 (4):635-42en
dc.identifier.issn1176-9106
dc.identifier.pmid18268938
dc.identifier.urihttp://hdl.handle.net/2336/20072
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractIndividuals with COPD have systemic inflammation that can be assessed by measuring C-reactive protein (CRP). In this paper we evaluated whether CRP is related to COPD, lung function and rate of lung function decline. We included 1237 randomly selected subjects (mean age 42, range 28-56 years) from three centers in the European Community Respiratory Health Survey: Reykjavik, Uppsala and Tartu. CRP was measured at the end of the follow-up (mean 8.3 years) and the values were divided into 4 quartiles. Fifty-three non-asthmatic subjects fulfilled spirometric criteria for COPD (FEV1/FVC < 70%). COPD occurred more often in the 4th CRP quartile (OR (95% CI) 3.21 (1.13-9.08)) after adjustment for age, gender, body weight and smoking. High CRP levels were related to lower FEV1 values in both men (-437 (-596, -279) mL) and women (-144 (-243, -44) mL). The negative association between CRP and FEV1 was significantly larger in men than women (p = 0.04). The decline in FEV1 was larger (16 (5, 27) mL) in men with high CRP levels whereas no significant association between CRP and FEV1 decline was found in women. Higher CRP values are significantly associated with COPD and lower lung function in men and women. In men higher CRP values are related to a larger decline in FEV1.
dc.language.isoenen
dc.publisherDOVE Medical Pressen
dc.relation.urlhttp://dovepress.com/articles.php?content_id=1929en
dc.subject.meshC-Reactive Proteinen
dc.subject.meshPubMed - in processen
dc.subject.meshPulmonary Disease, Chronic Obstructiveen
dc.subject.meshSpirometryen
dc.subject.meshBody Mass Indexen
dc.titleGender differences in the association between C-reactive protein, lung function impairment, and COPD.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden. inga_sif.olafsdottir@medsci.uu.seen
dc.identifier.journalInternational journal of chronic obstructive pulmonary diseaseen
html.description.abstractIndividuals with COPD have systemic inflammation that can be assessed by measuring C-reactive protein (CRP). In this paper we evaluated whether CRP is related to COPD, lung function and rate of lung function decline. We included 1237 randomly selected subjects (mean age 42, range 28-56 years) from three centers in the European Community Respiratory Health Survey: Reykjavik, Uppsala and Tartu. CRP was measured at the end of the follow-up (mean 8.3 years) and the values were divided into 4 quartiles. Fifty-three non-asthmatic subjects fulfilled spirometric criteria for COPD (FEV1/FVC < 70%). COPD occurred more often in the 4th CRP quartile (OR (95% CI) 3.21 (1.13-9.08)) after adjustment for age, gender, body weight and smoking. High CRP levels were related to lower FEV1 values in both men (-437 (-596, -279) mL) and women (-144 (-243, -44) mL). The negative association between CRP and FEV1 was significantly larger in men than women (p = 0.04). The decline in FEV1 was larger (16 (5, 27) mL) in men with high CRP levels whereas no significant association between CRP and FEV1 decline was found in women. Higher CRP values are significantly associated with COPD and lower lung function in men and women. In men higher CRP values are related to a larger decline in FEV1.


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