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Authors
Hardarson, Sveinn HakonHarris, Alon
Karlsson, Robert Arnar
Halldorsson, Gisli Hreinn
Kagemann, Larry
Rechtman, Ehud
Zoega, Gunnar Már
Eysteinsson, Thor
Benediktsson, Jon Atli
Thorsteinsson, Adalbjorn
Jensen, Peter Koch
Beach, James
Stefánsson, Einar
Issue Date
2006-11-01
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Invest. Ophthalmol. Vis. Sci. 2006, 47(11):5011-6Abstract
PURPOSE: To measure hemoglobin oxygen saturation (SO(2)) in retinal vessels and to test the reproducibility and sensitivity of an automatic spectrophotometric oximeter. METHODS: Specialized software automatically identifies the retinal blood vessels on fundus images, which are obtained with four different wavelengths of light. The software calculates optical density ratios (ODRs) for each vessel. The reproducibility was evaluated by analyzing five repeated measurements of the same vessels. A linear relationship between SO(2) and ODR was assumed and a linear model derived. After calibration, reproducibility and sensitivity were calculated in terms of SO(2). Systemic hyperoxia (n = 16) was induced in healthy volunteers by changing the O(2) concentration in inhaled air from 21% to 100%. RESULTS: The automatic software enhanced reproducibility, and the mean SD for repeated measurements was 3.7% for arterioles and 5.3% venules, in terms of percentage of SO(2) (five repeats, 10 individuals). The model derived for calibration was SO(2) = 125 - 142 . ODR. The arterial SO(2) measured 96% +/- 9% (mean +/- SD) during normoxia and 101% +/- 8% during hyperoxia (n = 16). The difference between normoxia and hyperoxia was significant (P = 0.0027, paired t-test). Corresponding numbers for venules were 55% +/- 14% and 78% +/- 15% (P < 0.0001). SO(2) is displayed as a pseudocolor map drawn on fundus images. CONCLUSIONS: The retinal oximeter is reliable, easy to use, and sensitive to changes in SO(2) when concentration of O(2) in inhaled air is changed.Description
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http://www.iovs.org/cgi/content/abstract/47/11/5011ae974a485f413a2113503eed53cd6c53
10.1167/iovs.06-0039
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