Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authorsvan Straaten, Elisabeth C W
Knol, Dirk L
van Buchem, Mark A
van Dijk, Ewout J
Hofman, Paul A M
de Leeuw, Frank-Erik
Prins, Niels D
Visser, Marieke C
Weinstein, Henry C
MetadataShow full item record
CitationOperational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study. 2003, 34 (8):1907-12 Stroke
AbstractBACKGROUND AND PURPOSE: Vascular dementia (VaD) is thought to be the most common cause of dementia after Alzheimer's disease. The commonly used International Workshop of the National Institute of Neurological Disorders and Stroke (NINDS) and the Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) criteria for VaD necessitate evidence of vascular disease on CT or MRI of the brain. The purposes of our study were to operationalize the radiological part of the NINDS-AIREN criteria and to assess the effect of this operationalization on interobserver agreement. METHODS: Six experienced and 4 inexperienced observers rated a set of 40 MRI studies of patients with clinically suspected VaD twice using the NINDS-AIREN set of radiological criteria. After the first reading session, operational definitions were conceived, which were subsequently used in the second reading session. Interobserver reproducibility was measured by Cohen's kappa. RESULTS: Overall agreement at the first reading session was poor (kappa=0.29) and improved slightly after application of the additional definitions (kappa=0.38). Raters in the experienced group improved their agreement from almost moderate (kappa=0.39) to good (0.62). The inexperienced group started out with poor agreement (kappa=0.17) and did not improve (kappa=0.18). The experienced group improved in both the large- and small-vessel categories, whereas the inexperienced group improved generally in the extensive white matter hyperintensities categories. CONCLUSIONS: Considerable interobserver variability exists for the assessment of the radiological part of the NINDS-AIREN criteria. Use of operational definitions improves agreement but only for already experienced observers.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Comparison of different clinical criteria (DSM-III, ADDTC, ICD-10, NINDS-AIREN, DSM-IV) for the diagnosis of vascular dementia. National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences.
- Authors: Pohjasvaara T, Mäntylä R, Ylikoski R, Kaste M, Erkinjuntti T
- Issue date: 2000 Dec
- Reliability of NINDS-AIREN clinical criteria for the diagnosis of vascular dementia.
- Authors: Lopez OL, Larumbe MR, Becker JT, Rezek D, Rosen J, Klunk W, DeKosky ST
- Issue date: 1994 Jul
- Clinicopathological validation study of four sets of clinical criteria for vascular dementia.
- Authors: Gold G, Bouras C, Canuto A, Bergallo MF, Herrmann FR, Hof PR, Mayor PA, Michel JP, Giannakopoulos P
- Issue date: 2002 Jan
- The diagnosis of vascular dementia in the light of the new criteria.
- Authors: Amar K, Wilcock GK, Scott M
- Issue date: 1996 Jan
- Impact of applying NINDS-AIREN criteria of probable vascular dementia to clinical and radiological characteristics of a stroke cohort with dementia.
- Authors: Tang WK, Chan SS, Chiu HF, Ungvari GS, Wong KS, Kwok TC, Mok V, Wong KT, Richards PS, Ahuja AT
- Issue date: 2004