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dc.contributor.authorGudjonsson, Johann E
dc.contributor.authorKarason, Ari
dc.contributor.authorRunarsdottir, E Hjaltey
dc.contributor.authorAntonsdottir, Arna A
dc.contributor.authorHauksson, Valdimar B
dc.contributor.authorJonsson, Hjortur H
dc.contributor.authorGulcher, Jeff
dc.contributor.authorStefansson, Kari
dc.contributor.authorValdimarsson, Helgi
dc.date.accessioned2008-03-25T13:35:26Z
dc.date.available2008-03-25T13:35:26Z
dc.date.issued2006-04-01
dc.date.submitted2008-03-25
dc.identifier.citationJ. Invest. Dermatol. 2006, 126(4):740-5en
dc.identifier.issn0022-202X
dc.identifier.pmid16439971
dc.identifier.doi10.1038/sj.jid.5700118
dc.identifier.urihttp://hdl.handle.net/2336/21472
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractA major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P<10(-10)), higher incidence of guttate and the eruptive type of psoriasis (P<0.0001), more frequent exacerbations with throat infections (P=0.01), higher incidence of the Koebner's phenomenon (P=0.01), and more extensive disease (P=0.03). A striking new finding was a diverging pattern of disease severity in HLA-Cw*0602 positive and negative patients depending on the age of onset of the disease (P=0.0006). HLA-Cw*0602 positive women also had more frequent remissions during pregnancy (P<0.0001). All types of nail changes were, however, more common in the Cw*0602 negative patients (P=0.003) and they more often had multiple types of nail lesions (P<0.0001). The three ancestral haplotypes of Cw*0602 all conferred an increase in odds ratio but showed no difference in any of the clinical features studied. Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/sj.jid.5700118en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshChromosomes, Human, Pair 6en
dc.subject.meshChronic Diseaseen
dc.subject.meshFemaleen
dc.subject.meshHLA-B Antigensen
dc.subject.meshHLA-C Antigensen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshPregnancyen
dc.subject.meshPsoriasisen
dc.subject.meshSeverity of Illness Indexen
dc.titleDistinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patientsen
dc.typeArticleen
dc.contributor.departmentNational University Hospital of Iceland, Reykjavik.en
dc.identifier.journalJournal of investigative dermatologyen
html.description.abstractA major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P<10(-10)), higher incidence of guttate and the eruptive type of psoriasis (P<0.0001), more frequent exacerbations with throat infections (P=0.01), higher incidence of the Koebner's phenomenon (P=0.01), and more extensive disease (P=0.03). A striking new finding was a diverging pattern of disease severity in HLA-Cw*0602 positive and negative patients depending on the age of onset of the disease (P=0.0006). HLA-Cw*0602 positive women also had more frequent remissions during pregnancy (P<0.0001). All types of nail changes were, however, more common in the Cw*0602 negative patients (P=0.003) and they more often had multiple types of nail lesions (P<0.0001). The three ancestral haplotypes of Cw*0602 all conferred an increase in odds ratio but showed no difference in any of the clinical features studied. Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.


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